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RECRUITING Phase 2

Post-op T-DM1 in HER-2+ Salivary Gland Carcinomas

NCT04620187 · View on ClinicalTrials.gov ↗

Study Summary

This research is being done to see how safe and effective the use of the study drug Ado-trastuzumab (T) emtansine (DM1), T-DM1, and standard of care chemoradiation are when used together in treating HER2-positive salivary gland cancer. It will also examine the effectiveness of study drug Ado-trastuzumab (T) emtansine (DM1) on cancer recurrence.

Interventions

  • DRUG Standard of Care Chemotherapy
  • DRUG Ado-trastuzumab (T) emtansine (T-DM1)
  • RADIATION Standard of Care Radiotherapy

Study Locations (12)

New York

  • Memorial Sloan Kettering Commack — Commack
  • Memorial Sloan Kettering Westchester — Harrison
  • David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center — New York
  • Memorial Sloan Kettering Cancer Center — New York
  • Memorial Sloan Kettering Nassau — Uniondale

New Jersey

  • Memorial Sloan Kettering Basking Ridge — Basking Ridge
  • Memorial Sloan Kettering Monmouth — Middletown
  • Memorial Sloan Kettering Bergen — Montvale

Massachusetts

  • Brigham and Women's Hospital — Boston
  • Dana Farber Cancer Institute — Boston

Illinois

  • University of Chicago — Chicago

Washington

  • University of Washington Medical Center — Seattle

Trial Details

FieldValue
Enrollment Target 55 participants
Start Date 2020-12-24
Est. Completion 2029-02-01
Phase Phase 2

Sponsor

Dana-Farber Cancer Institute

819 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04620187

The ClinicalTrials.gov registry entry for NCT04620187 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 55 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Dana-Farber Cancer Institute, which has 819 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Salivary Gland Cancer appearing as the primary indexed condition, and to 3 interventions — of which Standard of Care Chemotherapy is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04620187 reports 12 study locations spanning 5 distinct geographic areas — top geographies include New York, New Jersey, Massachusetts. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04620187 about?

NCT04620187 is a clinical study titled "Post-op T-DM1 in HER-2+ Salivary Gland Carcinomas". This research is being done to see how safe and effective the use of the study drug Ado-trastuzumab (T) emtansine (DM1), T-DM1, and standard of care chemoradiation are when used together in treating HER2-positive salivary gland cancer. It will also examine the effectiveness of study drug Ado-trastuz...

What is the current status of trial NCT04620187?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 55 participants. The study started on 2020-12-24. Estimated completion is 2029-02-01.

What conditions does trial NCT04620187 study?

This clinical trial studies the following conditions: Salivary Gland Cancer, HER2 Gene Mutation. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04620187?

The interventions under investigation include: Standard of Care Chemotherapy (DRUG), Ado-trastuzumab (T) emtansine (T-DM1) (DRUG), Standard of Care Radiotherapy (RADIATION). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04620187?

This trial is sponsored by Dana-Farber Cancer Institute, which has 819 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04620187 being conducted?

This trial has 12 study locations across Illinois, Massachusetts, New Jersey, New York, Washington. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial