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COMPLETED Phase 1

Tariquidar-ondansetron Combination in Neuropathic Pain

NCT04603066 · View on ClinicalTrials.gov ↗

Study Summary

Prospective, randomized, double-blind, placebo controlled, cross-over proof of concept study. To determine the pharmacokinetics and tolerability of co-administration of 5-HT3R antagonist ondansetron with a P-glycoprotein inhibitor tariquidar, in patients with neuropathic pain.

Conditions Studied

Interventions

  • DRUG Ondansetron 16 mg with Tariquidar
  • DRUG Ondansetron 16 mg with Placebo

Study Locations (1)

Missouri

  • Washington University School of Medicine/Barnes-Jewish Hospital — St Louis

Trial Details

FieldValue
Enrollment Target 24 participants
Start Date 2021-01-31
Est. Completion 2023-11-03
Phase Phase 1

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04603066

The ClinicalTrials.gov registry entry for NCT04603066 describes a study currently listed as completed. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 24 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Washington University School of Medicine, which has 1,036 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Neuropathic Pain appearing as the primary indexed condition, and to 2 interventions — of which Ondansetron 16 mg with Tariquidar is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04603066 reports 1 study location spanning 1 distinct geographic area — top geographies include Missouri. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04603066 about?

NCT04603066 is a clinical study titled "Tariquidar-ondansetron Combination in Neuropathic Pain". Prospective, randomized, double-blind, placebo controlled, cross-over proof of concept study. To determine the pharmacokinetics and tolerability of co-administration of 5-HT3R antagonist ondansetron with a P-glycoprotein inhibitor tariquidar, in patients with neuropathic pain.

What is the current status of trial NCT04603066?

This trial is currently completed. It is a Phase 1 study. The enrollment target is 24 participants. The study started on 2021-01-31. Estimated completion is 2023-11-03.

What conditions does trial NCT04603066 study?

This clinical trial studies the following conditions: Neuropathic Pain. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04603066?

The interventions under investigation include: Ondansetron 16 mg with Tariquidar (DRUG), Ondansetron 16 mg with Placebo (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04603066?

This trial is sponsored by Washington University School of Medicine, which has 1,036 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04603066 being conducted?

This trial has 1 study location across Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial