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NCT04602650 · ClinicalTrials.gov registry record
Microbial Determinants of Dementia Risk in Type 2 Diabetics of Mexican Descent
A clinical trial of Diabetes, sponsored by The University of Texas Medical Branch, Galveston.
- Completed
- Registry status
- 12
- Enrollment target
- 1
- Study location
NCT04602650: Completed study of Diabetes, sponsored by The University of Texas Medical Branch, Galveston.
NCT04602650 is a study of Diabetes that has completed, run by The University of Texas Medical Branch, Galveston. The registered enrollment target is 12 participants, below the 3,028-participant average among 338 other Diabetes trials with a reported enrollment target (100% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04602650, a study of Diabetes, has completed, sponsored by The University of Texas Medical Branch, Galveston.
- COMPLETED
- Registry status
- 12 participants
- Enrollment target
- 1
- Study location
Study Summary
Type 2 diabetes (T2D) predisposes individuals to neurodegeneration and dementia, including Alzheimer's Disease (AD); yet the link between metabolic and neurodegenerative disorders remains unknown. Here, the investigators will study a well-defined human population with increased prevalence and early onset of both T2D and AD, individuals of Mexican descent living in South Texas. The study will begin to explore the possibility that disruption of the structure of the bacterial community residing in the gut in type 2 diabetic individuals of Mexican descent living in South Texas is directly related to the increased prevalence of early onset AD in this population. In this study, the investigators will perform gene sequencing on DNA isolated from fecal samples to identify and compare the populations of bacteria living in individuals with T2D versus non-diabetic controls. The investigators will analyze the findings to determine if the community structure of the gut microbiome of individuals of Mexican descent with T2D is significantly altered compared to that of non-diabetics within the same population. The investigators' findings could lead to the identification of early indicators of dementia onset as well as novel therapies for treating metabolic and neurodegenerative diseases.
Primary Outcome
Metagenomic 16S ribosomal RNA (rRNA) gene sequencing will be performed on subject samples to determine the presence and measure the relative abundance of operational taxonomic units representative of bacterial genera, species, and strains present in the fecal sample.
Conditions Studied
Study Locations (1)
Texas
- University of Texas Medical Branch - Galveston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 12 participants |
| Start Date | 2021-01-14 |
| Est. Completion | 2022-12-31 |
What the finished NCT04602650 record still lists
NCT04602650 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 12 participants, a relatively small participant target, below the 3,028-participant average among 338 other Diabetes trials with a reported enrollment target (100% lower).
The record links to 1 condition, with Diabetes appearing as the primary indexed condition, and to 0 interventions.
NCT04602650 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT04602650 about?
NCT04602650 is a clinical study titled "Microbial Determinants of Dementia Risk in Type 2 Diabetics of Mexican Descent". Type 2 diabetes (T2D) predisposes individuals to neurodegeneration and dementia, including Alzheimer's Disease (AD); yet the link between metabolic and neurodegenerative disorders remains unknown. Here, the investigators will study a well-defined human population with increased prevalence and early ...
What is the current status of trial NCT04602650?
This trial is currently completed. The enrollment target is 12 participants. The study started on 2021-01-14. Estimated completion is 2022-12-31.
What conditions does trial NCT04602650 study?
This clinical trial studies the following conditions: Diabetes.
Who is sponsoring clinical trial NCT04602650?
This trial is sponsored by The University of Texas Medical Branch, Galveston, which has 203 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04602650 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT04602650's enrollment target sits among peer trials
12 326th of 338 higher than 10 of 338 other Diabetes trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Diabetes trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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