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NCT03366168 · ClinicalTrials.gov registry record
Taste Bud-Derived Stem Cells in Humans
A clinical trial of Diabetes, sponsored by National Institute on Aging (NIA).
- Recruiting
- Registry status
- 250
- Enrollment target
- 1
- Study location
NCT03366168: Recruiting study of Diabetes, sponsored by National Institute on Aging (NIA).
NCT03366168 is a study of Diabetes that is actively recruiting participants, run by National Institute on Aging (NIA). The registered enrollment target is 250 participants, below the 3,028-participant average among 338 other Diabetes trials with a reported enrollment target (92% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03366168, a study of Diabetes, is actively recruiting participants, sponsored by National Institute on Aging (NIA).
- RECRUITING
- Registry status
- 250 participants
- Enrollment target
- 1
- Study location
Study Summary
Background: Stem cells are found in body tissues. They can regenerate into more of the same cells or become other types of cell. Researchers want to use stem cells from taste buds to try to make cells that secrete insulin. Taste buds are found mostly on the tip and sides of the tongue. Researchers also want to study if the number of taste buds and stem cells decrease as people age. They will remove small pieces of tongue tissue (about the size of a pen tip). The taste buds will grow back. It is hoped that studying taste bud stem cells can lead to new diabetes treatments. Objectives: To see if stem cells from taste buds can be isolated in humans. Eligibility: Healthy adults at least 18 years old Design: Participants will be screened with: * Medical history * Physical exam * Blood and urine tests * Tongue photograph and mouth inspection. Food coloring will be applied to the tongue. Participants will have 1 study visit. They will not eat or drink anything 8 hours before. * They will give blood and urine samples. * They will have a tongue biopsy. Vital signs will be checked. The inside of the mouth will be examined. The tongue may be cleaned. The tongue will be numbed. Five small pieces of tissue will be taken with a small scissor. Any bleeding will be blotted with cotton and should stop in minutes. * Participants will be monitored for about 30 minutes. They will get a snack or meal. * They will be told how to take care of the tongue for the rest of the day. Participants will be called a week later to see how the
Primary Outcome
Stem cells will be isolated from the taste buds within the fungiform papillae, propagated in vitro, and then differentiated into glucose responsive insulin secreting cells.
Conditions Studied
Study Locations (1)
Maryland
- National Institute of Aging, Clinical Research Unit - Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 250 participants |
| Start Date | 2017-12-18 |
| Est. Completion | 2026-12-31 |
What NCT03366168 shows while recruiting
NCT03366168 is an observational study that tracks outcomes without assigning an intervention. The registered 250 participants enrollment target is mid-sized for trials with a published cap, below the 3,028-participant average among 338 other Diabetes trials with a reported enrollment target (92% lower).
The record links to 1 condition, with Diabetes appearing as the primary indexed condition, and to 0 interventions.
NCT03366168 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT03366168 about?
NCT03366168 is a clinical study titled "Taste Bud-Derived Stem Cells in Humans". Background: Stem cells are found in body tissues. They can regenerate into more of the same cells or become other types of cell. Researchers want to use stem cells from taste buds to try to make cells that secrete insulin. Taste buds are found mostly on the tip and sides of the tongue. Researchers ...
What is the current status of trial NCT03366168?
This trial is currently recruiting. The enrollment target is 250 participants. The study started on 2017-12-18. Estimated completion is 2026-12-31.
What conditions does trial NCT03366168 study?
This clinical trial studies the following conditions: Diabetes.
Who is sponsoring clinical trial NCT03366168?
This trial is sponsored by National Institute on Aging (NIA), which has 131 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03366168 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03366168's enrollment target sits among peer trials
250 125th of 338 higher than 211 of 338 other Diabetes trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Diabetes trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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