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NCT04600973 · ClinicalTrials.gov registry record · NA
Improving Implementation of Evidence-based Approaches and Surveillance to Prevent Bacterial Transmission and Infection
A NA study of Infection, sponsored by Trustees of Dartmouth College.
- Recruiting
- Registry status
- NA
- Development phase
- 6,000
- Enrollment target
- 2
- Study locations
NCT04600973: Recruiting NA study of Infection, sponsored by Trustees of Dartmouth College.
NCT04600973 is a NA study of Infection that is actively recruiting participants, run by Trustees of Dartmouth College. The registered enrollment target is 6,000 participants, above the 580-participant average among 41 other Infection trials with a reported enrollment target (934% higher). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04600973, a NA study of Infection, is actively recruiting participants, sponsored by Trustees of Dartmouth College.
- RECRUITING
- Registry status
- NA
- Development phase
- 6,000 participants
- Enrollment target
- 2
- Study locations
Study Summary
Surgical site infections (SSIs) are associated with increased patient morbidity, mortality, and healthcare costs. ESKAPE (Enterococcus, S. aureus, Klebsiella, Acinetobacter, Pseudomonas, and Enterobacter spp.) pathogens are particularly pathogenic because they have increased capacity to acquire resistance and virulence traits. The investigators have proven that a multifaceted program involving improved basic perioperative preventive measures can generate substantial reductions in S. aureus transmission and significant reductions in SSIs (88% reduction as compared to usual care). In this study, the investigators aim to examine the relative effectiveness of each component of this program in controlling ESKAPE transmission and reducing SSIs and to identify an optimal implementation strategy for national dissemination. Randomization occurs at the site level, and sites adopt preventative programs. This work will improve perioperative patient safety for the 51 million patients who undergo surgery each year.
Primary Outcome
One or more epidemiologically related ESKAPE pathogen transmission events (Enterococcus, S. aureus, Klebsiella, Acinetobacter, Pseudomonas, Enterobacter spp.) occurring in a perioperative observational unit. ESKAPE transmission will be defined as ≥ 2 ESKAPE isolates of the same class obtained from ≥ 2 distinct, temporally-associated reservoirs and/or the isolation of ≥ 1 ESKAPE pathogen from a reservoir at case end that was not present at case start, a definition tightly associated with SSI.
Conditions Studied
Interventions
- BEHAVIORAL Technical assistance or team-based coaching
Study Locations (2)
Minnesota
- Mayo Clinic - Rochester
New Hampshire
- Trustees of Dartmouth College - Hanover
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 6,000 participants |
| Start Date | 2021-07-01 |
| Est. Completion | 2026-06-30 |
| Phase | NA |
What NCT04600973 shows while recruiting
NCT04600973 is an interventional study that assigns participants to a tested intervention. Its 6,000 participants enrollment target places it among the larger protocols in the corpus, above the 580-participant average among 41 other Infection trials with a reported enrollment target (934% higher).
The record links to 1 condition, with Infection appearing as the primary indexed condition, and to 1 intervention - of which Technical assistance or team-based coaching is the first listed.
NCT04600973 reports a single indexed study location in Minnesota, New Hampshire.
Frequently Asked Questions
What is clinical trial NCT04600973 about?
NCT04600973 is a clinical study titled "Improving Implementation of Evidence-based Approaches and Surveillance to Prevent Bacterial Transmission and Infection". Surgical site infections (SSIs) are associated with increased patient morbidity, mortality, and healthcare costs. ESKAPE (Enterococcus, S. aureus, Klebsiella, Acinetobacter, Pseudomonas, and Enterobacter spp.) pathogens are particularly pathogenic because they have increased capacity to acquire resi...
What is the current status of trial NCT04600973?
This trial is currently recruiting. It is a NA study. The enrollment target is 6,000 participants. The study started on 2021-07-01. Estimated completion is 2026-06-30.
What conditions does trial NCT04600973 study?
This clinical trial studies the following conditions: Infection.
What interventions are being tested in trial NCT04600973?
The interventions under investigation include: Technical assistance or team-based coaching (BEHAVIORAL).
Who is sponsoring clinical trial NCT04600973?
This trial is sponsored by Trustees of Dartmouth College, which has 31 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04600973 being conducted?
This trial has 2 study locations across Minnesota, New Hampshire. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Infection
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04600973's enrollment target sits among peer trials
6,000 2nd of 41 the highest of 41 other Infection trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Infection trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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