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NCT04599088 · ClinicalTrials.gov registry record · NA
Investigation of Brain Mechanisms Involved in the Urinary Continence Mechanism Associated With Aging
A NA study of Urgency Urinary Incontinence, sponsored by University of Pittsburgh.
- Active
- Registry status
- NA
- Development phase
- 207
- Enrollment target
- 1
- Study location
NCT04599088: Active NA study of Urgency Urinary Incontinence, sponsored by University of Pittsburgh.
NCT04599088 is a NA study of Urgency Urinary Incontinence that is active but no longer recruiting, run by University of Pittsburgh. The registered enrollment target is 207 participants, below the 246-participant average among 4 other Urgency Urinary Incontinence trials with a reported enrollment target (16% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04599088, a NA study of Urgency Urinary Incontinence, is active but no longer recruiting, sponsored by University of Pittsburgh.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 207 participants
- Enrollment target
- 1
- Study location
Study Summary
Urge urinary incontinence (UUI) is a common problem in older people which vastly reduces quality of life, yet the cause and mechanism of disease are not well understood. This study will characterize brain control of the bladder in young and old continent individuals and age-matched incontinent counterparts. This will expand the investigators current knowledge of how the brain controls the bladder, how that control changes with age and disease, and suggest new targets to guide development of better treatment.
Primary Outcome
BOLD signal contrast - voxel-wise subtraction of normalized brain activity signal measure (BOLD response) during bladder fluid withdrawal from that during bladder infusion in the a priori defined mPFC region. Since BOLD signal represents the normalized contrast in fMRI signal between two states as a proxy for cerebral blood flow, it does not have a unit.
Conditions Studied
Interventions
- OTHER Brain functional MRI with simplified urodynamics
Study Locations (1)
Pennsylvania
- University of Pittsburgh - Pittsburgh
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 207 participants |
| Start Date | 2020-12-14 |
| Est. Completion | 2026-04-01 |
| Phase | NA |
What the registry record for NCT04599088 still lists
NCT04599088 is an interventional study that assigns participants to a tested intervention. The registered 207 participants enrollment target is mid-sized for trials with a published cap, below the 246-participant average among 4 other Urgency Urinary Incontinence trials with a reported enrollment target (16% lower).
The record links to 1 condition, with Urgency Urinary Incontinence appearing as the primary indexed condition, and to 1 intervention - of which Brain functional MRI with simplified urodynamics is the first listed.
NCT04599088 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT04599088 about?
NCT04599088 is a clinical study titled "Investigation of Brain Mechanisms Involved in the Urinary Continence Mechanism Associated With Aging". Urge urinary incontinence (UUI) is a common problem in older people which vastly reduces quality of life, yet the cause and mechanism of disease are not well understood. This study will characterize brain control of the bladder in young and old continent individuals and age-matched incontinent count...
What is the current status of trial NCT04599088?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 207 participants. The study started on 2020-12-14. Estimated completion is 2026-04-01.
What conditions does trial NCT04599088 study?
This clinical trial studies the following conditions: Urgency Urinary Incontinence.
What interventions are being tested in trial NCT04599088?
The interventions under investigation include: Brain functional MRI with simplified urodynamics (OTHER).
Who is sponsoring clinical trial NCT04599088?
This trial is sponsored by University of Pittsburgh, which has 1,238 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04599088 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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