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NCT04523376 · ClinicalTrials.gov registry record · NA
Pilot Study PBSCT with TCRab Depletion for Hemoglobinopathies
A NA study of Sickle Cell Disease and Thalassemia Major, sponsored by Timothy Olson.
- Active
- Registry status
- NA
- Development phase
- 9
- Enrollment target
- 1
- Study location
NCT04523376 is a NA study of Sickle Cell Disease and Thalassemia Major that is active but no longer recruiting, run by Timothy Olson. The registered enrollment target is 9 participants, below the 293-participant average among 213 other Sickle Cell Disease trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state.
The verdict
NCT04523376, a NA study of Sickle Cell Disease and Thalassemia Major, is active but no longer recruiting, sponsored by Timothy Olson.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 9 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a single arm pilot study of peripheral stem cell transplantation (PSCT) with ex vivo t-cell receptor alpha beta+(TCRαβ+) T cell and cluster of differentiation 19+ beta (CD19+ B) cell depletion of unrelated donor (URD) grafts using the CliniMACS device in patients with sickle cell disease (SCD) and beta thalassemia major (BTM).
Conditions Studied
Interventions
- DEVICE CliniMACS
Study Locations (1)
Pennsylvania
- Children's Hospital of Philadelphia - Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 9 participants |
| Start Date | 2020-05-14 |
| Est. Completion | 2027-06-01 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04523376
The ClinicalTrials.gov registry entry for NCT04523376 describes a study currently listed as active not recruiting, categorized as NA. The registered enrollment target is 9 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 293-participant average among 213 other Sickle Cell Disease trials with a reported enrollment target (97% lower). The listed sponsor is Timothy Olson, which has 1 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Sickle Cell Disease appearing as the primary indexed condition, and to 1 intervention - of which CliniMACS is the first listed.
NCT04523376 reports 1 study location spanning 1 distinct geographic area - top geographies include Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT04523376 about?
NCT04523376 is a clinical study titled "Pilot Study PBSCT with TCRab Depletion for Hemoglobinopathies". This is a single arm pilot study of peripheral stem cell transplantation (PSCT) with ex vivo t-cell receptor alpha beta+(TCRαβ+) T cell and cluster of differentiation 19+ beta (CD19+ B) cell depletion of unrelated donor (URD) grafts using the CliniMACS device in patients with sickle cell disease (SC...
What is the current status of trial NCT04523376?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 9 participants. The study started on 2020-05-14. Estimated completion is 2027-06-01.
What conditions does trial NCT04523376 study?
This clinical trial studies the following conditions: Sickle Cell Disease, Thalassemia Major.
What interventions are being tested in trial NCT04523376?
The interventions under investigation include: CliniMACS (DEVICE).
Who is sponsoring clinical trial NCT04523376?
This trial is sponsored by Timothy Olson, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04523376 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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