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NCT04484623 · ClinicalTrials.gov registry record · Phase 3
Belantamab Mafodotin Plus Pomalidomide and Dexamethasone (Pd) Versus Bortezomib Plus Pd in Relapsed/Refractory Multiple Myeloma
A Phase 3 study of Multiple Myeloma, sponsored by GlaxoSmithKline.
- Active
- Registry status
- Phase 3
- Development phase
- 302
- Enrollment target
- 20
- Study locations
NCT04484623: Active Phase 3 study of Multiple Myeloma, sponsored by GlaxoSmithKline.
NCT04484623 is a Phase 3 study of Multiple Myeloma that is active but no longer recruiting, run by GlaxoSmithKline. The registered enrollment target is 302 participants, below the 546-participant average among 438 other Multiple Myeloma trials with a reported enrollment target (45% lower). The trial reports 20 study locations across 12 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04484623, a Phase 3 study of Multiple Myeloma, is active but no longer recruiting, sponsored by GlaxoSmithKline.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 3
- Development phase
- 302 participants
- Enrollment target
- 20
- Study locations
Study Summary
This study will evaluate the efficacy and safety of belantamab mafodotin in combination with pomalidomide and dexamethasone (Arm A) compared with that of combination of pomalidomide, bortezomib and dexamethasone (Arm B) in participants with relapsed/refractory multiple myeloma (RRMM).
Primary Outcome
PFS is defined as time from randomization until earliest date of disease progression (PD), determined by Independent Review Committee (IRC), according to the International Myeloma Working Group (IMWG) Response Criteria, or death due to any cause. PD is defined as increase of \>=25% from lowest value in \>=1 of following (serum M-protein \[absolute increase \>=0.5 grams per deciliter {g/dL}\]; serum M-protein increase \>=1g/dL \[when lowest M-protein \>=5g/dL\]; urine M-protein \[absolute increas
Conditions Studied
Interventions
- DRUG Belantamab mafodotin
- DRUG Dexamethasone
- DRUG Pomalidomide
- DRUG Bortezomib
Study Locations (20)
Other
- GSK Investigational Site - Curitiba
- GSK Investigational Site - Joinville
- GSK Investigational Site - Porto Alegre
- GSK Investigational Site - São Paulo
New South Wales
- GSK Investigational Site - Darlinghurst
- GSK Investigational Site - Gosford NSW
- GSK Investigational Site - Port Macquarie
Victoria
- GSK Investigational Site - Fitzroy
- GSK Investigational Site - Heidelberg
- GSK Investigational Site - Malvern
Queensland
- GSK Investigational Site - Benowa
- GSK Investigational Site - South Brisbane
Arizona
- GSK Investigational Site - Tucson
Florida
- GSK Investigational Site - Fort Myers
Massachusetts
- GSK Investigational Site - Boston
Missouri
- GSK Investigational Site - Kansas City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 302 participants |
| Start Date | 2020-10-01 |
| Est. Completion | 2029-10-25 |
| Phase | Phase 3 |
What the registry record for NCT04484623 still lists
NCT04484623 is an interventional study that assigns participants to a tested intervention. The registered 302 participants enrollment target is mid-sized for trials with a published cap, below the 546-participant average among 438 other Multiple Myeloma trials with a reported enrollment target (45% lower).
The record links to 1 condition, with Multiple Myeloma appearing as the primary indexed condition, and to 4 interventions - of which Belantamab mafodotin is the first listed.
NCT04484623 names 20 study sites across 12 states, led by Other, New South Wales, Victoria.
Frequently Asked Questions
What is clinical trial NCT04484623 about?
NCT04484623 is a clinical study titled "Belantamab Mafodotin Plus Pomalidomide and Dexamethasone (Pd) Versus Bortezomib Plus Pd in Relapsed/Refractory Multiple Myeloma". This study will evaluate the efficacy and safety of belantamab mafodotin in combination with pomalidomide and dexamethasone (Arm A) compared with that of combination of pomalidomide, bortezomib and dexamethasone (Arm B) in participants with relapsed/refractory multiple myeloma (RRMM).
What is the current status of trial NCT04484623?
This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 302 participants. The study started on 2020-10-01. Estimated completion is 2029-10-25.
What conditions does trial NCT04484623 study?
This clinical trial studies the following conditions: Multiple Myeloma.
What interventions are being tested in trial NCT04484623?
The interventions under investigation include: Belantamab mafodotin (DRUG), Dexamethasone (DRUG), Pomalidomide (DRUG), Bortezomib (DRUG).
Who is sponsoring clinical trial NCT04484623?
This trial is sponsored by GlaxoSmithKline, which has 1,345 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04484623 being conducted?
This trial has 20 study locations across Arizona, Florida, Massachusetts, Missouri, Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Multiple Myeloma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04484623's enrollment target sits among peer trials
302 74th of 438 higher than 365 of 438 other Multiple Myeloma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Multiple Myeloma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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