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NCT04483440 · ClinicalTrials.gov registry record · Phase 1

Dose Escalation Study of Intravitreal 4D-110 in Patients With Choroideremia

A Phase 1 study of Choroideremia, sponsored by 4D Molecular Therapeutics.

Active
Registry status
Phase 1
Development phase
13
Enrollment target
2
Study locations

NCT04483440 is a Phase 1 study of Choroideremia that is active but no longer recruiting, run by 4D Molecular Therapeutics. The registered enrollment target is 13 participants, below the 3,133-participant average among 7 other Choroideremia trials with a reported enrollment target (100% lower). The trial reports 2 study locations across 2 states.

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The verdict

NCT04483440, a Phase 1 study of Choroideremia, is active but no longer recruiting, sponsored by 4D Molecular Therapeutics.

ACTIVE NOT RECRUITING
Registry status
Phase 1
Development phase
13 participants
Enrollment target
2
Study locations

Study Summary

This study will evaluate safety, tolerability, and preliminary efficacy of a single intravitreal (IVT) injection of a recombinant adeno-associated virus (AAV) gene therapy, 4D-110, in male patients with genetically-confirmed Choroideremia (CHM).

Conditions Studied

Choroideremia

Interventions

  • BIOLOGICAL 4D-110

Study Locations (2)

Texas

  • Retina Foundation of the Southwest - Dallas

Utah

  • Moran Eye Center, University of Utah - Salt Lake City

Trial Details

FieldValue
Enrollment Target 13 participants
Start Date 2020-06-02
Est. Completion 2027-08-31
Phase Phase 1

Sponsor

4D Molecular Therapeutics

9 total trials

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What the Registry Record Tells You About NCT04483440

The ClinicalTrials.gov registry entry for NCT04483440 describes a study currently listed as active not recruiting, categorized as Phase 1. The registered enrollment target is 13 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 3,133-participant average among 7 other Choroideremia trials with a reported enrollment target (100% lower). The listed sponsor is 4D Molecular Therapeutics, which has 9 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Choroideremia appearing as the primary indexed condition, and to 1 intervention - of which 4D-110 is the first listed.

NCT04483440 reports 2 study locations spanning 2 distinct geographic areas - top geographies include Texas, Utah.

Frequently Asked Questions

What is clinical trial NCT04483440 about?

NCT04483440 is a clinical study titled "Dose Escalation Study of Intravitreal 4D-110 in Patients With Choroideremia". This study will evaluate safety, tolerability, and preliminary efficacy of a single intravitreal (IVT) injection of a recombinant adeno-associated virus (AAV) gene therapy, 4D-110, in male patients with genetically-confirmed Choroideremia (CHM).

What is the current status of trial NCT04483440?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 13 participants. The study started on 2020-06-02. Estimated completion is 2027-08-31.

What conditions does trial NCT04483440 study?

This clinical trial studies the following conditions: Choroideremia.

What interventions are being tested in trial NCT04483440?

The interventions under investigation include: 4D-110 (BIOLOGICAL).

Who is sponsoring clinical trial NCT04483440?

This trial is sponsored by 4D Molecular Therapeutics, which has 9 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT04483440 being conducted?

This trial has 2 study locations across Texas, Utah. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.