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NCT04392271 · ClinicalTrials.gov registry record · Phase 1

A Study of the Effects of Multiple Doses of LY3372689 on the Brain in Healthy Participants

A Phase 1 study of Healthy, sponsored by Eli Lilly and Company.

Completed
Registry status
Phase 1
Development phase
4
Enrollment target
1
Study location

NCT04392271: Completed Phase 1 study of Healthy, sponsored by Eli Lilly and Company.

NCT04392271 is a Phase 1 study of Healthy that has completed, run by Eli Lilly and Company. The registered enrollment target is 4 participants, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT04392271, a Phase 1 study of Healthy, has completed, sponsored by Eli Lilly and Company.

COMPLETED
Registry status
Phase 1
Development phase
4 participants
Enrollment target
1
Study location

Study Summary

This study uses imaging to evaluate how LY3372689 binds to a protein in the brain. This study will be conducted in healthy participants and will last up to about 10 weeks. Screening must be completed within four weeks prior to enrollment.

Primary Outcome

Percent OGA EO

Conditions Studied

Interventions

  • DRUG LY3372689
  • DIAGNOSTIC_TEST [18F]LSN3316612

Study Locations (1)

Connecticut

  • Institute for Neurodegenerative Disorders - New Haven

Trial Details

FieldValue
Enrollment Target 4 participants
Start Date 2020-08-06
Est. Completion 2020-10-14
Phase Phase 1
Eli Lilly and Company

1,341 total trials

What the finished NCT04392271 record still lists

NCT04392271 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 4 participants, a relatively small participant target, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (99% lower).

The record links to 1 condition, with Healthy appearing as the primary indexed condition, and to 2 interventions - of which LY3372689 is the first listed.

NCT04392271 reports a single indexed study location in Connecticut.

Frequently Asked Questions

What is clinical trial NCT04392271 about?

NCT04392271 is a clinical study titled "A Study of the Effects of Multiple Doses of LY3372689 on the Brain in Healthy Participants". This study uses imaging to evaluate how LY3372689 binds to a protein in the brain. This study will be conducted in healthy participants and will last up to about 10 weeks. Screening must be completed within four weeks prior to enrollment.

What is the current status of trial NCT04392271?

This trial is currently completed. It is a Phase 1 study. The enrollment target is 4 participants. The study started on 2020-08-06. Estimated completion is 2020-10-14.

What conditions does trial NCT04392271 study?

This clinical trial studies the following conditions: Healthy.

What interventions are being tested in trial NCT04392271?

The interventions under investigation include: LY3372689 (DRUG), [18F]LSN3316612 (DIAGNOSTIC_TEST).

Who is sponsoring clinical trial NCT04392271?

This trial is sponsored by Eli Lilly and Company, which has 1,341 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT04392271 being conducted?

This trial has 1 study location across Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Similar trials for Healthy

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT04392271's enrollment target sits among peer trials

4 1087th of 1090 higher than 1 of 1,090 other Healthy trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Healthy trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.

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Source: ClinicalTrials.gov NCT04392271, the US trial registry maintained by the National Library of Medicine. NCT04392271 (small enrollment · single site footprint · completed) retrieved and formatted by PlainTrial, see methodology.