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NCT04343560 · ClinicalTrials.gov registry record
MACS and Healthy Volunteers Bone Study
A clinical trial, sponsored by Mayo Clinic.
- Completed
- Registry status
- 380
- Enrollment target
NCT04343560: Completed study, sponsored by Mayo Clinic.
NCT04343560 is a clinical trial that has completed, run by Mayo Clinic. The registered enrollment target is 380 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04343560 has completed, sponsored by Mayo Clinic.
- COMPLETED
- Registry status
- 380 participants
- Enrollment target
Study Summary
Adrenal adenoma is detected in 5-7% of adults and demonstrates mild autonomous cortisol secretion (MACS, dexamethasone suppression test \>1.8 mcg/dl) in 50% of individuals with adenoma. Published reports suggest a 48%-52% 2-year incidence of new vertebral fractures in patients with MACS without any significant changes in bone density measurements. A disproportionate decrease in bone quality versus density or other factors such as sarcopenia potentially contribute to development of new vertebral fractures. Determining which specific abnormalities in the steroid metabolome affect bone density, quality and strength as well as bone remodeling markers and body composition will potentially serve as a diagnostic biomarker of clinical significance.
Primary Outcome
measured by computed tomography
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 380 participants |
| Start Date | 2019-02-21 |
| Est. Completion | 2023-12-11 |
What the finished NCT04343560 record still lists
NCT04343560 is an observational study that tracks outcomes without assigning an intervention. The registered 380 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 0 interventions.
NCT04343560 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04343560 about?
NCT04343560 is a clinical study titled "MACS and Healthy Volunteers Bone Study". Adrenal adenoma is detected in 5-7% of adults and demonstrates mild autonomous cortisol secretion (MACS, dexamethasone suppression test \>1.8 mcg/dl) in 50% of individuals with adenoma. Published reports suggest a 48%-52% 2-year incidence of new vertebral fractures in patients with MACS without any ...
What is the current status of trial NCT04343560?
This trial is currently completed. The enrollment target is 380 participants. The study started on 2019-02-21. Estimated completion is 2023-12-11.
Who is sponsoring clinical trial NCT04343560?
This trial is sponsored by Mayo Clinic, which has 2,844 total clinical trials registered on ClinicalTrials.gov.
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