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NCT04216784 · ClinicalTrials.gov registry record · Phase 4
Compare the Diuretic Effect With Furosemide vs Furosemide and Albumin Combined in Cirrhotic Patients
A Phase 4 study, sponsored by Rush University Medical Center.
- Terminated
- Registry status
- Phase 4
- Development phase
- 21
- Enrollment target
NCT04216784 is a Phase 4 study that was terminated before completion, run by Rush University Medical Center. The registered enrollment target is 21 participants.
The verdict
NCT04216784, a Phase 4 study, was terminated before completion, sponsored by Rush University Medical Center.
- TERMINATED
- Registry status
- Phase 4
- Development phase
- 21 participants
- Enrollment target
Study Summary
A common complication of the progression of cirrhosis is fluid retention (ascites, edema, or pleural effusion). Loop diuretics are the treatment of choice for fluid retention in cirrhotic patients; however, many of these patients demonstrate diuretic resistance, requiring higher doses of the diuretics to achieve adequate diuresis. The cause of this diuretic resistance is hypothesized to be secondary to hypoalbuminemia which has led some providers to give human albumin in combination with loop diuretics to increase intravascular volume and facilitate diuresis. However, this practice remains controversial because minimal data exists to support its efficacy. The purpose of this study is to compare the efficacy of diuretics alone versus diuretics in combination with albumin in cirrhotic patients presenting with fluid retention.
Interventions
- DRUG Albumin Human
- DRUG Furosemide Injection
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 21 participants |
| Start Date | 2019-12-19 |
| Est. Completion | 2024-04-01 |
| Phase | Phase 4 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04216784
The ClinicalTrials.gov registry entry for NCT04216784 describes a study currently listed as terminated, categorized as Phase 4. The registered enrollment target is 21 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Rush University Medical Center, which has 320 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Albumin Human is the first listed.
NCT04216784 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT04216784 about?
NCT04216784 is a clinical study titled "Compare the Diuretic Effect With Furosemide vs Furosemide and Albumin Combined in Cirrhotic Patients". A common complication of the progression of cirrhosis is fluid retention (ascites, edema, or pleural effusion). Loop diuretics are the treatment of choice for fluid retention in cirrhotic patients; however, many of these patients demonstrate diuretic resistance, requiring higher doses of the diureti...
What is the current status of trial NCT04216784?
This trial is currently terminated. It is a Phase 4 study. The enrollment target is 21 participants. The study started on 2019-12-19. Estimated completion is 2024-04-01.
What interventions are being tested in trial NCT04216784?
The interventions under investigation include: Albumin Human (DRUG), Furosemide Injection (DRUG).
Who is sponsoring clinical trial NCT04216784?
This trial is sponsored by Rush University Medical Center, which has 320 total clinical trials registered on ClinicalTrials.gov.
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