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NCT04165616 · ClinicalTrials.gov registry record
Motor rECovery witH eArly imagiNg In STroke
A clinical trial of Stroke, sponsored by Northwestern University.
- Recruiting
- Registry status
- 120
- Enrollment target
- 3
- Study locations
NCT04165616: Recruiting study of Stroke, sponsored by Northwestern University.
NCT04165616 is a study of Stroke that is actively recruiting participants, run by Northwestern University. The registered enrollment target is 120 participants, below the 12,016-participant average among 454 other Stroke trials with a reported enrollment target (99% lower). The trial reports 3 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04165616, a study of Stroke, is actively recruiting participants, sponsored by Northwestern University.
- RECRUITING
- Registry status
- 120 participants
- Enrollment target
- 3
- Study locations
Study Summary
This study will contribute to the field of stroke rehabilitation research by expanding the investigator's understanding of the neural mechanisms responsible for the development and expression of abnormal flexion synergy, a primary movement impairment due to stroke. The study will longitudinally evaluate motor tract morphology and motor impairment/function in an attempt to develop early neuroimaging-based predictors of the development of flexion synergy and its impact on reaching and hand recovery (6 month). The study will utilize quantitative motor testing (kinematics and kinetics) to measure motor impairment and reaching and hand function. Both neuroimaging and quantitative motor testing will be conducted within 96 hours-, 2 weeks-, 3 months-, and 6 months-post stroke. The knowledge gained by this study will provide crucial structural and functional neuroimaging evidence that demonstrates the timeline of progressive ipsi- and contralesional motor pathway (including bulbospinal pathways) changes and the associated development of flexion synergy that grossly impacts reaching and hand function in individuals with moderate to severe stroke.
Primary Outcome
Fractional anisotropy is a quantitative measure of fiber density, axonal diameter, and myelination in the corticofugal, corticoreticulospinal, and corticorubrospinal tracts derived from the diffusion tensor imaging dataset.
Conditions Studied
Study Locations (3)
Illinois
- Department of Physical Therapy and Human Movement Sciences - Chicago
- Northwestern Memorial Hospital - Chicago
- Shirley Ryan AbilityLab - Chicago
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 120 participants |
| Start Date | 2022-06-21 |
| Est. Completion | 2026-04-30 |
What NCT04165616 shows while recruiting
NCT04165616 is an observational study that tracks outcomes without assigning an intervention. The registered 120 participants enrollment target is mid-sized for trials with a published cap, below the 12,016-participant average among 454 other Stroke trials with a reported enrollment target (99% lower).
The record links to 1 condition, with Stroke appearing as the primary indexed condition, and to 0 interventions.
NCT04165616 reports a single indexed study location in Illinois.
Frequently Asked Questions
What is clinical trial NCT04165616 about?
NCT04165616 is a clinical study titled "Motor rECovery witH eArly imagiNg In STroke". This study will contribute to the field of stroke rehabilitation research by expanding the investigator's understanding of the neural mechanisms responsible for the development and expression of abnormal flexion synergy, a primary movement impairment due to stroke. The study will longitudinally eval...
What is the current status of trial NCT04165616?
This trial is currently recruiting. The enrollment target is 120 participants. The study started on 2022-06-21. Estimated completion is 2026-04-30.
What conditions does trial NCT04165616 study?
This clinical trial studies the following conditions: Stroke.
Who is sponsoring clinical trial NCT04165616?
This trial is sponsored by Northwestern University, which has 1,209 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04165616 being conducted?
This trial has 3 study locations across Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Stroke
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04165616's enrollment target sits among peer trials
120 117th of 454 higher than 329 of 454 other Stroke trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Stroke trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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