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NCT04154332 · ClinicalTrials.gov registry record
Exosome Cargo From Preeclampsia Patients
A clinical trial of Preeclampsia, sponsored by University of Alabama at Birmingham.
- Recruiting
- Registry status
- 64
- Enrollment target
- 1
- Study location
NCT04154332 is a study of Preeclampsia that is actively recruiting participants, run by University of Alabama at Birmingham. The registered enrollment target is 64 participants, below the 1,280-participant average among 39 other Preeclampsia trials with a reported enrollment target (95% lower). The trial reports 1 study location across 1 state.
The verdict
NCT04154332, a study of Preeclampsia, is actively recruiting participants, sponsored by University of Alabama at Birmingham.
- RECRUITING
- Registry status
- 64 participants
- Enrollment target
- 1
- Study location
Study Summary
Although extensively studied, the cause of preeclampsia remains uncertain other than it is thought that the placenta plays a critical role in the development of preeclampsia. Recent data revealed that exosomes released from the placenta could cause preeclampsia by transporting specific cargo responsible for the pathophysiological changes associated with the systemic disease. By isolating these exosomes from maternal blood and placental tissue in patients diagnosed with preeclampsia and studying their biochemical, cellular and molecular mechanism in an animal model, the investigators hope to elucidate the critical role that exosomal cargo plays in the development of preeclampsia and cardiovascular remodeling. This will be accomplished by obtaining patient samples from volunteers delivering at the Women and Infants Center and taking the samples to the lab for quantification, characterization, and identification of key functional roles through in/ex vivo, in vitro, and profiling studies. The investigators believe this work will be valuable as hope exists to define the functional role exosomes play in the development of preeclampsia that leads to cardiovascular remodeling. Data from this study will shed more light on the functional role of exosomal cargo in normal and pathological pregnancies and point towards novel therapeutic intervention strategies for preeclampsia associated with cardiovascular disease.
Conditions Studied
Interventions
- OTHER Sample collection
Study Locations (1)
Alabama
- University of Alabama at Birmingham - Birmingham
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 64 participants |
| Start Date | 2019-12-02 |
| Est. Completion | 2026-12-15 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04154332
The ClinicalTrials.gov registry entry for NCT04154332 describes a study currently listed as recruiting, categorized as an unspecified phase. The registered enrollment target is 64 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 1,280-participant average among 39 other Preeclampsia trials with a reported enrollment target (95% lower). The listed sponsor is University of Alabama at Birmingham, which has 1,160 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Preeclampsia appearing as the primary indexed condition, and to 1 intervention - of which Sample collection is the first listed.
NCT04154332 reports 1 study location spanning 1 distinct geographic area - top geographies include Alabama.
Frequently Asked Questions
What is clinical trial NCT04154332 about?
NCT04154332 is a clinical study titled "Exosome Cargo From Preeclampsia Patients". Although extensively studied, the cause of preeclampsia remains uncertain other than it is thought that the placenta plays a critical role in the development of preeclampsia. Recent data revealed that exosomes released from the placenta could cause preeclampsia by transporting specific cargo respons...
What is the current status of trial NCT04154332?
This trial is currently recruiting. The enrollment target is 64 participants. The study started on 2019-12-02. Estimated completion is 2026-12-15.
What conditions does trial NCT04154332 study?
This clinical trial studies the following conditions: Preeclampsia.
What interventions are being tested in trial NCT04154332?
The interventions under investigation include: Sample collection (OTHER).
Who is sponsoring clinical trial NCT04154332?
This trial is sponsored by University of Alabama at Birmingham, which has 1,160 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04154332 being conducted?
This trial has 1 study location across Alabama. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.