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NCT04138615 · ClinicalTrials.gov registry record · Phase 1
Analgesics in the Pre-hospital Setting: Implications on Hemorrhage Tolerance - Morphine
A Phase 1 study of Healthy, sponsored by University of Texas Southwestern Medical Center.
- Completed
- Registry status
- Phase 1
- Development phase
- 44
- Enrollment target
- 1
- Study location
NCT04138615: Completed Phase 1 study of Healthy, sponsored by University of Texas Southwestern Medical Center.
NCT04138615 is a Phase 1 study of Healthy that has completed, run by University of Texas Southwestern Medical Center. The registered enrollment target is 44 participants, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (93% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04138615, a Phase 1 study of Healthy, has completed, sponsored by University of Texas Southwestern Medical Center.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 44 participants
- Enrollment target
- 1
- Study location
Study Summary
We are examining how morphine (a commonly used pain medication) will alter responses to simulated blood loss in humans. To simulate blood loss in our research laboratory, participants will complete a test with their lower body in a custom-designed vacuum chamber for a brief period of time.
Primary Outcome
Tolerance to a simulated hemorrhagic challenge will be assessed, for both the placebo and morphine limbs, by causing progressive central hypovolemia via lower-body negative pressure (LBNP). This progressive LBNP challenge will be performed until the onset of syncopal symptoms (defined as: profound bradycardia, a precipitous drop in arterial blood pressure and accompanying narrowing of pulse pressure, a sustained systolic blood pressure less than 80 mmHg, and/or subjective symptoms such as light-
Conditions Studied
Interventions
- OTHER Placebo
- DRUG Morphine
Study Locations (1)
Texas
- University of Texas Southwestern Medical Center - Dallas
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 44 participants |
| Start Date | 2019-11-12 |
| Est. Completion | 2022-01-04 |
| Phase | Phase 1 |
What the finished NCT04138615 record still lists
NCT04138615 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 44 participants, a relatively small participant target, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (93% lower).
The record links to 1 condition, with Healthy appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT04138615 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT04138615 about?
NCT04138615 is a clinical study titled "Analgesics in the Pre-hospital Setting: Implications on Hemorrhage Tolerance - Morphine". We are examining how morphine (a commonly used pain medication) will alter responses to simulated blood loss in humans. To simulate blood loss in our research laboratory, participants will complete a test with their lower body in a custom-designed vacuum chamber for a brief period of time.
What is the current status of trial NCT04138615?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 44 participants. The study started on 2019-11-12. Estimated completion is 2022-01-04.
What conditions does trial NCT04138615 study?
This clinical trial studies the following conditions: Healthy.
What interventions are being tested in trial NCT04138615?
The interventions under investigation include: Placebo (OTHER), Morphine (DRUG).
Who is sponsoring clinical trial NCT04138615?
This trial is sponsored by University of Texas Southwestern Medical Center, which has 837 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04138615 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Healthy
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04138615's enrollment target sits among peer trials
44 506th of 1090 higher than 570 of 1,090 other Healthy trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Healthy trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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