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NCT04049227 · ClinicalTrials.gov registry record · Early Phase 1
Abemaciclib and Letrozole in Treating Patients With Endometrial Cancer
A Early Phase 1 study of Endometrial Endometrioid Adenocarcinoma, sponsored by Northwestern University.
- Completed
- Registry status
- Early Phase 1
- Development phase
- 27
- Enrollment target
- 2
- Study locations
NCT04049227: Completed Early Phase 1 study of Endometrial Endometrioid Adenocarcinoma, sponsored by Northwestern University.
NCT04049227 is a Early Phase 1 study of Endometrial Endometrioid Adenocarcinoma that has completed, run by Northwestern University. The registered enrollment target is 27 participants, below the 277-participant average among 6 other Endometrial Endometrioid Adenocarcinoma trials with a reported enrollment target (90% lower). The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04049227, a Early Phase 1 study of Endometrial Endometrioid Adenocarcinoma, has completed, sponsored by Northwestern University.
- COMPLETED
- Registry status
- Early Phase 1
- Development phase
- 27 participants
- Enrollment target
- 2
- Study locations
Study Summary
This early phase I trial studies how well abemaciclib and letrozole work in treating patients with endometrial cancer and determines whether there are changes in patients' cancer cell biomarkers (a genetic feature or specific protein) for cell growth before and after treatment. Antihormone therapy with aromatase inhibitors, such as letrozole, may lessen the amount of estrogen made by the body. Abemaciclib blocks the activities of a class of proteins called cyclin-dependent kinase, which are involved in cell duplication. Giving letrozole and abemaciclib together may slow down cancer cell growth in patients with endometrial cancer.
Conditions Studied
Interventions
- DRUG Letrozole
- DRUG Abemaciclib
- PROCEDURE Therapeutic Conventional Surgery
Study Locations (2)
Illinois
- Northwestern University - Chicago
- University of Chicago Comprehensive Cancer Center - Chicago
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 27 participants |
| Start Date | 2019-08-12 |
| Est. Completion | 2023-05-15 |
| Phase | Early Phase 1 |
What the finished NCT04049227 record still lists
NCT04049227 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 27 participants, a relatively small participant target, below the 277-participant average among 6 other Endometrial Endometrioid Adenocarcinoma trials with a reported enrollment target (90% lower).
The record links to 1 condition, with Endometrial Endometrioid Adenocarcinoma appearing as the primary indexed condition, and to 3 interventions - of which Letrozole is the first listed.
NCT04049227 reports a single indexed study location in Illinois.
Frequently Asked Questions
What is clinical trial NCT04049227 about?
NCT04049227 is a clinical study titled "Abemaciclib and Letrozole in Treating Patients With Endometrial Cancer". This early phase I trial studies how well abemaciclib and letrozole work in treating patients with endometrial cancer and determines whether there are changes in patients' cancer cell biomarkers (a genetic feature or specific protein) for cell growth before and after treatment. Antihormone therapy w...
What is the current status of trial NCT04049227?
This trial is currently completed. It is a Early Phase 1 study. The enrollment target is 27 participants. The study started on 2019-08-12. Estimated completion is 2023-05-15.
What conditions does trial NCT04049227 study?
This clinical trial studies the following conditions: Endometrial Endometrioid Adenocarcinoma.
What interventions are being tested in trial NCT04049227?
The interventions under investigation include: Letrozole (DRUG), Abemaciclib (DRUG), Therapeutic Conventional Surgery (PROCEDURE).
Who is sponsoring clinical trial NCT04049227?
This trial is sponsored by Northwestern University, which has 1,209 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04049227 being conducted?
This trial has 2 study locations across Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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