Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

NCT03981575 · ClinicalTrials.gov registry record

Estab Biomarkers and Clinical Endpoints in Myotonic Dystrophy Type 1 (END-DM1)

A clinical trial of Myotonic Dystrophy 1 and DM1, sponsored by Virginia Commonwealth University.

Recruiting
Registry status
700
Enrollment target
17
Study locations

NCT03981575: Recruiting study of Myotonic Dystrophy 1 and DM1, sponsored by Virginia Commonwealth University.

NCT03981575 is a study of Myotonic Dystrophy 1 and DM1 that is actively recruiting participants, run by Virginia Commonwealth University. The registered enrollment target is 700 participants, below the 938-participant average among 4 other Myotonic Dystrophy 1 trials with a reported enrollment target (25% lower). The trial reports 17 study locations across 10 states. According to ClinicalTrials.gov, the official US trial registry.

View on ClinicalTrials.gov ↗

View your shortlist →

The verdict

NCT03981575, a study of Myotonic Dystrophy 1 and DM1, is actively recruiting participants, sponsored by Virginia Commonwealth University.

RECRUITING
Registry status
700 participants
Enrollment target
17
Study locations

Study Summary

Building on previous work of the Myotonic Dystrophy Clinical Research Network (DMCRN), the present study seeks to overcome insufficient data on natural history; lack of reliable biomarkers; and incomplete characterization and limited biological understanding of the phenotypic heterogeneity of Myotonic Dystrophy 1 by examining strategies to improve the reliability by making further refinements in our sample collection and analysis procedures by developing strategies for managing patient heterogeneity going forward. Funding Source- FDA OOPD

Primary Outcome

10 meter walk will be measured (m/s)

Conditions Studied

Myotonic Dystrophy 1 DM1

Study Locations (17)

Other

  • Université de Sherbrooke - Québec
  • Friedrich Baur Institute, Ludwig-Maximilians-Universität München - München
  • Centro Clinico NeMO - Milan
  • Radboud University Medical Center - Nijmegen
  • University of Auckland - Auckland
  • St. George's, University of London - London
  • University College London - London

California

  • University of California, San Diego - La Jolla
  • University of California, Los Angeles - Los Angeles

Colorado

  • University of Colorado - Denver - Denver

Florida

  • University of Florida - Gainesville

Iowa

  • University of Iowa - Iowa City

Kansas

  • Kansas University Medical Center - Kansas City

New York

  • University of Rochester - Rochester

Ohio

  • Ohio State University - Columbus

Trial Details

FieldValue
Enrollment Target 700 participants
Start Date 2019-01-01
Est. Completion 2026-12-01
Virginia Commonwealth University

558 total trials

What NCT03981575 shows while recruiting

NCT03981575 is an observational study that tracks outcomes without assigning an intervention. The registered 700 participants enrollment target is mid-sized for trials with a published cap, below the 938-participant average among 4 other Myotonic Dystrophy 1 trials with a reported enrollment target (25% lower).

The record links to 2 conditions, with Myotonic Dystrophy 1 appearing as the primary indexed condition, and to 0 interventions.

NCT03981575 lists 17 locations in 10 states (Other, California, Colorado).

Frequently Asked Questions

What is clinical trial NCT03981575 about?

NCT03981575 is a clinical study titled "Estab Biomarkers and Clinical Endpoints in Myotonic Dystrophy Type 1 (END-DM1)". Building on previous work of the Myotonic Dystrophy Clinical Research Network (DMCRN), the present study seeks to overcome insufficient data on natural history; lack of reliable biomarkers; and incomplete characterization and limited biological understanding of the phenotypic heterogeneity of Myoton...

What is the current status of trial NCT03981575?

This trial is currently recruiting. The enrollment target is 700 participants. The study started on 2019-01-01. Estimated completion is 2026-12-01.

What conditions does trial NCT03981575 study?

This clinical trial studies the following conditions: Myotonic Dystrophy 1, DM1.

Who is sponsoring clinical trial NCT03981575?

This trial is sponsored by Virginia Commonwealth University, which has 558 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT03981575 being conducted?

This trial has 17 study locations across California, Colorado, Florida, Iowa, Kansas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Myotonic Dystrophy 1

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Nationwide trials with similar profiles

Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.

Similar enrollment target

  • NCT00900419 · 700 participants

    Biomarkers in Patients With Respiratory Tract Dysplasia or Lung Cancer, Head and Neck Cancer, or Aerodigestive Tract Cancer and in Normal Volunteers

  • NCT01804686 · 700 participants · Phase 3

    A Long-term Extension Study of PCI-32765 (Ibrutinib)

  • NCT02107989 · 700 participants

    Noninvasive Pre-surgical Evaluation of Patients With Focal Epilepsy and Establishment of a Normative Imaging Database

  • NCT02129543 · 700 participants

    Immune Reconstitution in Stem Cell Transplant Recipients

Similar registry start date

  • NCT05962346 · started 2026-12 · NA

    Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia

  • NCT07125183 · started 2026-12 · Phase 2

    Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma

  • NCT07292298 · started 2026-11 · Phase 2

    Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates

  • NCT04263285 · started 2026-10 · NA

    Treatment of Depression Post-SCI

More recruiting context for NCT03981575

Source: ClinicalTrials.gov NCT03981575, the US trial registry maintained by the National Library of Medicine. NCT03981575 (mid enrollment · multi site footprint · recruiting) retrieved and formatted by PlainTrial, see methodology.