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ACTIVE NOT RECRUITING Phase 3

Global Study of Del-desiran for the Treatment of DM1

NCT06411288 · View on ClinicalTrials.gov ↗

Study Summary

A Phase 3 Randomized, Double-Blind, Placebo-Controlled, Global Study to Evaluate the Efficacy and Safety of Intravenous Delpacibart Etedesiran (abbreviated del-desiran, formerly AOC 1001) for the Treatment of Myotonic Dystrophy Type 1

Interventions

  • DRUG Placebo
  • DRUG AOC 1001 (del-desiran)

Study Locations (20)

Florida

  • University of Florida — Gainesville
  • University Research Center of South Florida — Tampa

North Carolina

  • Duke University Medical Center — Durham
  • Wake Forest — Winston-Salem

Ohio

  • University of Cincinnati Gardner Neuroscience Institute — Cincinnati
  • Ohio State University — Columbus

California

  • Stanford University — Stanford

Colorado

  • University of Colorado — Denver

Indiana

  • Indiana University (IU) — Indianapolis

Kansas

  • Kansas University Medical Center — Kansas City

Maryland

  • Kennedy Krieger Institute — Baltimore

Trial Details

FieldValue
Enrollment Target 159 participants
Start Date 2024-05-30
Est. Completion 2026-09
Phase Phase 3

Sponsor

Avidity Biosciences

6 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06411288

The ClinicalTrials.gov registry entry for NCT06411288 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 159 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Avidity Biosciences, which has 6 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 10 conditions, with Myotonic Dystrophy appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06411288 reports 20 study locations spanning 17 distinct geographic areas — top geographies include Florida, North Carolina, Ohio. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06411288 about?

NCT06411288 is a clinical study titled "Global Study of Del-desiran for the Treatment of DM1". A Phase 3 Randomized, Double-Blind, Placebo-Controlled, Global Study to Evaluate the Efficacy and Safety of Intravenous Delpacibart Etedesiran (abbreviated del-desiran, formerly AOC 1001) for the Treatment of Myotonic Dystrophy Type 1

What is the current status of trial NCT06411288?

This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 159 participants. The study started on 2024-05-30. Estimated completion is 2026-09.

What conditions does trial NCT06411288 study?

This clinical trial studies the following conditions: Myotonic Dystrophy, Myotonic Dystrophy 1, DM1, Myotonic Dystrophy Type 1 (DM1), Myotonic Muscular Dystrophy. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06411288?

The interventions under investigation include: Placebo (DRUG), AOC 1001 (del-desiran) (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06411288?

This trial is sponsored by Avidity Biosciences, which has 6 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06411288 being conducted?

This trial has 20 study locations across California, Colorado, Florida, Indiana, Kansas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial