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NCT03968445 · ClinicalTrials.gov registry record · Phase 1

Neuroinflammation After Myocardial Infarction - Imaging Substudy

A Phase 1 study of Myocardial Infarction, sponsored by University of Alabama at Birmingham.

Active
Registry status
Phase 1
Development phase
6
Enrollment target
1
Study location

NCT03968445: Active Phase 1 study of Myocardial Infarction, sponsored by University of Alabama at Birmingham.

NCT03968445 is a Phase 1 study of Myocardial Infarction that is active but no longer recruiting, run by University of Alabama at Birmingham. The registered enrollment target is 6 participants, below the 4,682-participant average among 64 other Myocardial Infarction trials with a reported enrollment target (100% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT03968445, a Phase 1 study of Myocardial Infarction, is active but no longer recruiting, sponsored by University of Alabama at Birmingham.

ACTIVE NOT RECRUITING
Registry status
Phase 1
Development phase
6 participants
Enrollment target
1
Study location

Study Summary

The purpose of the study is to see if positron emission tomography and magnetic resonance imaging (PET/MRI) with an investigational drug called \[18F\]DPA-714 will show inflammation in the brain after a heart attack. This study may help physicians and researchers better understand the role of brain inflammation in heart disease and develop new treatments to protect the brain.

Primary Outcome

The regional brain concentrations of \[F-18\]DPA-714, a PET imaging marker of neuroinflammation, will be compared between study participants who have recently been hospitalized for acute myocardial infarction (AMI) and a control group undergoing elective percutaneous coronary interventions (PCI).

Conditions Studied

Myocardial Infarction

Interventions

  • DRUG [18F]DPA-714-PET/MRI

Study Locations (1)

Alabama

  • University of Alabama at Birmingham Medical Center - Birmingham

Trial Details

FieldValue
Enrollment Target 6 participants
Start Date 2019-10-17
Est. Completion 2028-10
Phase Phase 1
University of Alabama at Birmingham

1,160 total trials

What the registry record for NCT03968445 still lists

NCT03968445 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 6 participants, a relatively small participant target, below the 4,682-participant average among 64 other Myocardial Infarction trials with a reported enrollment target (100% lower).

The record links to 1 condition, with Myocardial Infarction appearing as the primary indexed condition, and to 1 intervention - of which [18F]DPA-714-PET/MRI is the first listed.

NCT03968445 reports a single indexed study location in Alabama.

Frequently Asked Questions

What is clinical trial NCT03968445 about?

NCT03968445 is a clinical study titled "Neuroinflammation After Myocardial Infarction - Imaging Substudy". The purpose of the study is to see if positron emission tomography and magnetic resonance imaging (PET/MRI) with an investigational drug called \[18F\]DPA-714 will show inflammation in the brain after a heart attack. This study may help physicians and researchers better understand the role of brain ...

What is the current status of trial NCT03968445?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 6 participants. The study started on 2019-10-17. Estimated completion is 2028-10.

What conditions does trial NCT03968445 study?

This clinical trial studies the following conditions: Myocardial Infarction.

What interventions are being tested in trial NCT03968445?

The interventions under investigation include: [18F]DPA-714-PET/MRI (DRUG).

Who is sponsoring clinical trial NCT03968445?

This trial is sponsored by University of Alabama at Birmingham, which has 1,160 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT03968445 being conducted?

This trial has 1 study location across Alabama. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Myocardial Infarction

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT03968445's enrollment target sits among peer trials

6 65th of 64 the lowest of 64 other Myocardial Infarction trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Myocardial Infarction trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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Related registry views

Source: ClinicalTrials.gov NCT03968445, the US trial registry maintained by the National Library of Medicine. NCT03968445 (small enrollment · single site footprint · active not recruiting) retrieved and formatted by PlainTrial, see methodology.