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NCT03889158 · ClinicalTrials.gov registry record · Phase 4
Effect of Age and Fitness on Vascular Function and Oxidative Stress During Acute Inflammation
A Phase 4 study, sponsored by University of Illinois at Chicago.
- Terminated
- Registry status
- Phase 4
- Development phase
- 35
- Enrollment target
NCT03889158: Clinical Trial Phase 4 study, sponsored by University of Illinois at Chicago.
NCT03889158 is a Phase 4 study that was terminated before completion, run by University of Illinois at Chicago. The registered enrollment target is 35 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (93% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03889158, a Phase 4 study, was terminated before completion, sponsored by University of Illinois at Chicago.
- TERMINATED
- Registry status
- Phase 4
- Development phase
- 35 participants
- Enrollment target
Study Summary
This study focuses on whether high cardiorespiratory fitness in older adults has a protective effect on the vascular response to acute inflammation in comparison to low-fit older and young adults.
Primary Outcome
Flow-mediated dilation - Brachial artery vasodilator function will be noninvasively measured through assessment of brachial artery dilation using ultrasonography. The brachial artery will be imaged proximal to placement of a blood pressure cuff just below the antecubital fossa. Endothelium-dependent dilation of the brachial artery will be measured at baseline and again for 5 minutes following ischemic stimulus (inflation of a blood pressure cuff around the forearm to 250 mmHg for 5 minutes).
Interventions
- DIETARY_SUPPLEMENT Ascorbic Acid
- BIOLOGICAL Typhoid Vaccine
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 35 participants |
| Start Date | 2019-03-25 |
| Est. Completion | 2020-03-13 |
| Phase | Phase 4 |
Why NCT03889158 stopped before completion
NCT03889158 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 35 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (93% lower).
The record links to 0 conditions, and to 2 interventions - of which Ascorbic Acid is the first listed.
NCT03889158 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03889158 about?
NCT03889158 is a clinical study titled "Effect of Age and Fitness on Vascular Function and Oxidative Stress During Acute Inflammation". This study focuses on whether high cardiorespiratory fitness in older adults has a protective effect on the vascular response to acute inflammation in comparison to low-fit older and young adults.
What is the current status of trial NCT03889158?
This trial is currently terminated. It is a Phase 4 study. The enrollment target is 35 participants. The study started on 2019-03-25. Estimated completion is 2020-03-13.
What interventions are being tested in trial NCT03889158?
The interventions under investigation include: Ascorbic Acid (DIETARY_SUPPLEMENT), Typhoid Vaccine (BIOLOGICAL).
Who is sponsoring clinical trial NCT03889158?
This trial is sponsored by University of Illinois at Chicago, which has 430 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03889158's enrollment target sits among peer trials
35 1506th of 2000 higher than 481 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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