Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT03852537 · ClinicalTrials.gov registry record · Phase 2
Steroid Dosing by bioMARker Guided Titration in Critically Ill Patients With Pneumonia
A Phase 2 study of Pneumonia, sponsored by Mayo Clinic.
- Completed
- Registry status
- Phase 2
- Development phase
- 44
- Enrollment target
- 1
- Study location
NCT03852537: Completed Phase 2 study of Pneumonia, sponsored by Mayo Clinic.
NCT03852537 is a Phase 2 study of Pneumonia that has completed, run by Mayo Clinic. The registered enrollment target is 44 participants, below the 4,519-participant average among 47 other Pneumonia trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03852537, a Phase 2 study of Pneumonia, has completed, sponsored by Mayo Clinic.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 44 participants
- Enrollment target
- 1
- Study location
Study Summary
This research study is being done to determine the appropriate dose of steroids and the appropriate duration for steroid use to reduce inflammation in severe pneumonia needing a form of breathing support. This study seeks to compare usual care to a unique (individualized) dosing strategy. A marker of inflammation in the body will be measured in blood samples. This marker of inflammation is called C- reactive protein. The overall goal is to identify patients that will benefit most from steroid use and decrease use of steroids. The information collected from this study may provide information that may improve management of patients with severe pneumonia requiring a form of breathing support.
Primary Outcome
Number of eligible subjects to adhered to the timely initiation and daily corticosteroid treatment according to ESICM/Society of Critical Care Medicine SCCM clinical practice guideline (control group) or biomarker concordance (intervention group)
Conditions Studied
Interventions
- OTHER Usual Care
- DRUG Methylprednisolone
Study Locations (1)
Minnesota
- Mayo Clinic in Rochester - Rochester
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 44 participants |
| Start Date | 2019-12-02 |
| Est. Completion | 2020-11-17 |
| Phase | Phase 2 |
What the finished NCT03852537 record still lists
NCT03852537 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 44 participants, a relatively small participant target, below the 4,519-participant average among 47 other Pneumonia trials with a reported enrollment target (99% lower).
The record links to 1 condition, with Pneumonia appearing as the primary indexed condition, and to 2 interventions - of which Usual Care is the first listed.
NCT03852537 reports a single indexed study location in Minnesota.
Frequently Asked Questions
What is clinical trial NCT03852537 about?
NCT03852537 is a clinical study titled "Steroid Dosing by bioMARker Guided Titration in Critically Ill Patients With Pneumonia". This research study is being done to determine the appropriate dose of steroids and the appropriate duration for steroid use to reduce inflammation in severe pneumonia needing a form of breathing support. This study seeks to compare usual care to a unique (individualized) dosing strategy. A marker o...
What is the current status of trial NCT03852537?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 44 participants. The study started on 2019-12-02. Estimated completion is 2020-11-17.
What conditions does trial NCT03852537 study?
This clinical trial studies the following conditions: Pneumonia.
What interventions are being tested in trial NCT03852537?
The interventions under investigation include: Usual Care (OTHER), Methylprednisolone (DRUG).
Who is sponsoring clinical trial NCT03852537?
This trial is sponsored by Mayo Clinic, which has 2,844 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03852537 being conducted?
This trial has 1 study location across Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Pneumonia
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03852537's enrollment target sits among peer trials
44 36th of 47 higher than 12 of 47 other Pneumonia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Pneumonia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Individualizing Corticosteroid Use in Pneumonia
RECRUITING · Phase 2
-
Phase 2a Multiple Ascending Dose Study in Hospitalized Patients With Pneumonia.
RECRUITING · Phase 2
-
Low-Dose Radiotherapy For Patients With SARS-COV-2 (COVID-19) Pneumonia
ACTIVE NOT RECRUITING · Phase 2
-
Convalescent Plasma for Treatment of COVID-19 Patients With Pneumonia
COMPLETED · Phase 2
-
A Study of Auxora in Patients With Severe COVID-19 Pneumonia
COMPLETED · Phase 2
-
Safety, Tolerability and Pharmacokinetics of Aerosolized Amikacin in Intubated and Mechanically-ventilated Patients With Nosocomial Pneumonia
COMPLETED · Phase 2
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT02323945 · 44 participants · NA
Effects of Breathing Mild Bouts of Low Oxygen on Limb Mobility After Spinal Injury
- NCT03093909 · 44 participants · Phase 1
Study of Aerosol Gemcitabine in Patients With Solid Tumors and Pulmonary Metastases
- NCT03104491 · 44 participants · Phase 1
Inotuzumab Ozogamicin Post-Transplant For Acute Lymphocytic Leukemia
- NCT03781765 · 44 participants · Phase 4
Stimulant vs. Non-stimulant Treatments and Reward Processing in Drug-naive Youth at SUD Risk
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI