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NCT03851302 · ClinicalTrials.gov registry record · NA
Effects of Remote Ischemic Conditioning on Hand Use in Individuals With SCI and ALS
A NA study, sponsored by Bronx VA Medical Center.
- Completed
- Registry status
- NA
- Development phase
- 21
- Enrollment target
NCT03851302: Completed NA study, sponsored by Bronx VA Medical Center.
NCT03851302 is a NA study that has completed, run by Bronx VA Medical Center. The registered enrollment target is 21 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03851302, a NA study, has completed, sponsored by Bronx VA Medical Center.
- COMPLETED
- Registry status
- NA
- Development phase
- 21 participants
- Enrollment target
Study Summary
Rehabilitation interventions such as physical training and neural stimulation after spinal cord injury (SCI) have been shown to increase neural plasticity. However, both physical training and neural stimulation require a large number of repetitions, and the retention of the intervention effects may be fleeting. In this proposal the investigators will test Remote ischemic conditioning (RIC), which has been shown to promote neural plasticity and has practical and theoretical advantages. RIC consists of transiently restricting blood flow to any 'remote' limb using a blood pressure cuff. This induces several of the body's systemic defensive reactions. RIC has been shown to improve motor learning. The investigators propose that RIC alters motor pathway excitability through a combination of systemic increases in plasticity-promoting factors and inhibition of inflammatory factors. The investigators have designed a clinical trial to test this hypothesis in 8 persons with SCI and 8 able-bodied controls. All participants will receive active/sham RIC plus a hand exercise. The investigators will measure effects on blood pressure, motor neuron excitability, and systemic inflammatory markers before and after RIC as well as after hand exercise. Starting July 2021, we will also enroll 5 individuals with Amyotrophic lateral sclerosis (ALS) in this study.
Primary Outcome
Response to electrical and magnetic stimulation will be measured via peak-to-peak amplitude (millivolts) in abductor pollicis brevis muscle. Percent change of the electromyographic responses was measured immediately after active/sham RIC plus isometric hand exercise in comparison with baseline measurement. The RIC plus hand exercise duration is 60 minutes.
Interventions
- OTHER Active Remote Ischemic Conditioning
- OTHER Sham Remote Ischemic Conditioning
- OTHER Isometric hand exercise
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 21 participants |
| Start Date | 2019-10-28 |
| Est. Completion | 2022-10-31 |
| Phase | NA |
What the finished NCT03851302 record still lists
NCT03851302 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 21 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 3 interventions - of which Active Remote Ischemic Conditioning is the first listed.
NCT03851302 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03851302 about?
NCT03851302 is a clinical study titled "Effects of Remote Ischemic Conditioning on Hand Use in Individuals With SCI and ALS". Rehabilitation interventions such as physical training and neural stimulation after spinal cord injury (SCI) have been shown to increase neural plasticity. However, both physical training and neural stimulation require a large number of repetitions, and the retention of the intervention effects may ...
What is the current status of trial NCT03851302?
This trial is currently completed. It is a NA study. The enrollment target is 21 participants. The study started on 2019-10-28. Estimated completion is 2022-10-31.
What interventions are being tested in trial NCT03851302?
The interventions under investigation include: Active Remote Ischemic Conditioning (OTHER), Sham Remote Ischemic Conditioning (OTHER), Isometric hand exercise (OTHER).
Who is sponsoring clinical trial NCT03851302?
This trial is sponsored by Bronx VA Medical Center, which has 13 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03851302's enrollment target sits among peer trials
21 1762nd of 2000 higher than 233 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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