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NCT03800342 · ClinicalTrials.gov registry record · NA
Recovery, Fatigability, and Proteomic Response to Aerobic Exercise Training in Healthy Individuals
A NA study, sponsored by George Mason University.
- Completed
- Registry status
- NA
- Development phase
- 21
- Enrollment target
NCT03800342: Completed NA study, sponsored by George Mason University.
NCT03800342 is a NA study that has completed, run by George Mason University. The registered enrollment target is 21 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03800342, a NA study, has completed, sponsored by George Mason University.
- COMPLETED
- Registry status
- NA
- Development phase
- 21 participants
- Enrollment target
Study Summary
The purpose of this protocol is to investigate the role of expired non-metabolic carbon dioxide in the relationship between fatigability and recovery and the response to aerobic exercise training in healthy individuals. Both fatigability and recovery are profoundly influenced by mitochondrial energetics which can be inhibited by ionic by-product accumulation during exercise. Buffering mechanisms of these fatigue-inducing ions releases non-metabolic carbon dioxide (CO2) that can be measured as expired CO2 (VCO2) during cardiopulmonary exercise testing (CPET), however the role of non-metabolic VCO2 in the relationship between fatigability and recovery has yet to be investigated. Furthermore, this study aims to identify the how the patterns of proteins in healthy individuals respond to aerobic exercise training (e.g. stationary cycling) over approximately one month. The underlying mechanisms of recovery after physical activity, including mechanisms or biological pathways that could be highlighted by analysis of proteins in urine, could add to scientific knowledge regarding physical activity tolerance and potential exercise interventions. This knowledge could eventually assist with designing precise and personalized exercise interventions to improve physical activity performance. The investigators hypothesize that 1) non-metabolic CO2 will be at least moderately associated with the inverse relationship between fatigability and recovery; and 2) highly active adults, compared to sedentary individuals, will exhibit differential proteomic patterns in response to an initial acute bout and subsequent repeated bouts of aerobic exercise.
Primary Outcome
Correlate measures of non-metabolic carbon dioxide (as measured by the contribution of total expired non-metabolic VCO2) with the correlative relationship between fatigability (as measured by total time during an endurance CPET and on-kinetics during a constant square-wave CPET) and recovery (as measured by VO2 and VCO2 following maximal and submaximal CPET). Compare changes in measures of non-metabolic carbon dioxide (as measured by the contribution of total expired non-metabolic VCO2) and chan
Interventions
- OTHER Aerobic Exercise Training
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 21 participants |
| Start Date | 2019-01-22 |
| Est. Completion | 2019-04-24 |
| Phase | NA |
What the finished NCT03800342 record still lists
NCT03800342 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 21 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 1 intervention - of which Aerobic Exercise Training is the first listed.
NCT03800342 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03800342 about?
NCT03800342 is a clinical study titled "Recovery, Fatigability, and Proteomic Response to Aerobic Exercise Training in Healthy Individuals". The purpose of this protocol is to investigate the role of expired non-metabolic carbon dioxide in the relationship between fatigability and recovery and the response to aerobic exercise training in healthy individuals. Both fatigability and recovery are profoundly influenced by mitochondrial energe...
What is the current status of trial NCT03800342?
This trial is currently completed. It is a NA study. The enrollment target is 21 participants. The study started on 2019-01-22. Estimated completion is 2019-04-24.
What interventions are being tested in trial NCT03800342?
The interventions under investigation include: Aerobic Exercise Training (OTHER).
Who is sponsoring clinical trial NCT03800342?
This trial is sponsored by George Mason University, which has 25 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03800342's enrollment target sits among peer trials
21 1762nd of 2000 higher than 233 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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