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NCT03800342 · ClinicalTrials.gov registry record · NA
Recovery, Fatigability, and Proteomic Response to Aerobic Exercise Training in Healthy Individuals
A NA study, sponsored by George Mason University.
- Completed
- Registry status
- NA
- Development phase
- 21
- Enrollment target
NCT03800342 is a NA study that has completed, run by George Mason University. The registered enrollment target is 21 participants.
The verdict
NCT03800342, a NA study, has completed, sponsored by George Mason University.
- COMPLETED
- Registry status
- NA
- Development phase
- 21 participants
- Enrollment target
Study Summary
The purpose of this protocol is to investigate the role of expired non-metabolic carbon dioxide in the relationship between fatigability and recovery and the response to aerobic exercise training in healthy individuals. Both fatigability and recovery are profoundly influenced by mitochondrial energetics which can be inhibited by ionic by-product accumulation during exercise. Buffering mechanisms of these fatigue-inducing ions releases non-metabolic carbon dioxide (CO2) that can be measured as expired CO2 (VCO2) during cardiopulmonary exercise testing (CPET), however the role of non-metabolic VCO2 in the relationship between fatigability and recovery has yet to be investigated. Furthermore, this study aims to identify the how the patterns of proteins in healthy individuals respond to aerobic exercise training (e.g. stationary cycling) over approximately one month. The underlying mechanisms of recovery after physical activity, including mechanisms or biological pathways that could be highlighted by analysis of proteins in urine, could add to scientific knowledge regarding physical activity tolerance and potential exercise interventions. This knowledge could eventually assist with designing precise and personalized exercise interventions to improve physical activity performance. The investigators hypothesize that 1) non-metabolic CO2 will be at least moderately associated with the inverse relationship between fatigability and recovery; and 2) highly active adults, compared to sedentary individuals, will exhibit differential proteomic patterns in response to an initial acute bout and subsequent repeated bouts of aerobic exercise.
Interventions
- OTHER Aerobic Exercise Training
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 21 participants |
| Start Date | 2019-01-22 |
| Est. Completion | 2019-04-24 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03800342
The ClinicalTrials.gov registry entry for NCT03800342 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 21 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is George Mason University, which has 25 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Aerobic Exercise Training is the first listed.
NCT03800342 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT03800342 about?
NCT03800342 is a clinical study titled "Recovery, Fatigability, and Proteomic Response to Aerobic Exercise Training in Healthy Individuals". The purpose of this protocol is to investigate the role of expired non-metabolic carbon dioxide in the relationship between fatigability and recovery and the response to aerobic exercise training in healthy individuals. Both fatigability and recovery are profoundly influenced by mitochondrial energe...
What is the current status of trial NCT03800342?
This trial is currently completed. It is a NA study. The enrollment target is 21 participants. The study started on 2019-01-22. Estimated completion is 2019-04-24.
What interventions are being tested in trial NCT03800342?
The interventions under investigation include: Aerobic Exercise Training (OTHER).
Who is sponsoring clinical trial NCT03800342?
This trial is sponsored by George Mason University, which has 25 total clinical trials registered on ClinicalTrials.gov.
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