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NCT03776682 · ClinicalTrials.gov registry record
Myocardial Inflammation in Rheumatoid Arthritis: A Descriptive Study
A clinical trial, sponsored by Mayo Clinic.
- Completed
- Registry status
- 35
- Enrollment target
NCT03776682: Completed study, sponsored by Mayo Clinic.
NCT03776682 is a clinical trial that has completed, run by Mayo Clinic. The registered enrollment target is 35 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03776682 has completed, sponsored by Mayo Clinic.
- COMPLETED
- Registry status
- 35 participants
- Enrollment target
Study Summary
Rheumatoid arthritis (RA) patients have a higher prevalence of subclinical atherosclerosis than the general population. In addition, RA patients experience higher rates of heart failure with preserved ejection fraction (HFpEF). There is evidence that myocardial mechanics and left ventricular diastolic function are more abnormal in the RA population and these changes occur earlier than in the general population. Recently a study suggested that RA patient have abnormal myocardial inflammation during a disease flare and that this is improved with anti-inflammatory treatment. This study is aimed at describing the prevalence of myocardial inflammation in patients during active RA disease flares and comparing that with RA patients who are in remission. Investigators hope to show that abnormalities in myocardial inflammation on PET imaging correlate with abnormalities in myocardial strain on echocardiography. Coronary CT will be performed to establish the presence of subclinical atherosclerosis and whether its presence affects changes in either myocardial inflammation or myocardial strain. The hypothesis is that patients with evidence of myocardial inflammation during the course of their RA disease are more likely to develop HFpEF during their lifetime. Although the present study will not be of a duration to assess outcome, it will provide descriptive data which may help guide future prospective study of patients with RA which may help guide appropriate cardiovascular testing in this high risk population.
Primary Outcome
To determine if myocardial F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) imaging in patients with rheumatoid arthritis reveals evidence of subclinical myocardial inflammation which correlate with level of systemic inflammatory burden.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 35 participants |
| Start Date | 2018-06-22 |
| Est. Completion | 2023-05-26 |
What the finished NCT03776682 record still lists
NCT03776682 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 35 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT03776682 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03776682 about?
NCT03776682 is a clinical study titled "Myocardial Inflammation in Rheumatoid Arthritis: A Descriptive Study". Rheumatoid arthritis (RA) patients have a higher prevalence of subclinical atherosclerosis than the general population. In addition, RA patients experience higher rates of heart failure with preserved ejection fraction (HFpEF). There is evidence that myocardial mechanics and left ventricular diastol...
What is the current status of trial NCT03776682?
This trial is currently completed. The enrollment target is 35 participants. The study started on 2018-06-22. Estimated completion is 2023-05-26.
Who is sponsoring clinical trial NCT03776682?
This trial is sponsored by Mayo Clinic, which has 2,844 total clinical trials registered on ClinicalTrials.gov.
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