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A Study to Evaluate Upadacitinib in Combination With Topical Corticosteroids in Adolescent and Adult Participants With Moderate to Severe Atopic Dermatitis
NCT03568318 · View on ClinicalTrials.gov ↗
Study Summary
The objective of this study is to assess the efficacy and safety of upadacitinib combined with topical corticosteroids (TCS) for the treatment of adolescent and adult participants with moderate to severe atopic dermatitis (AD) who are candidates for systemic therapy.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Upadacitinib
- DRUG Topical corticosteroids (TCS)
Study Locations (20)
California
- Bakersfield Derma & Skin Cance /ID# 200892 — Bakersfield
- Mosaic Dermatology /ID# 200553 — Beverly Hills
- University of California Irvine /ID# 200902 — Irvine
- Therapeutics Clinical Research /ID# 200593 — San Diego
- Stanford University /ID# 200597 — Stanford
Alabama
- Total Skin and Beauty Derm Ctr /ID# 200548 — Birmingham
- Clinical Research Center AL /ID# 201865 — Birmingham
- ACCEL Research Sites /ID# 213364 — Birmingham
- Advanced Dermatology and Skin Care Centre /ID# 213550 — Mobile
Arizona
- Alliance Dermatology and MOHs Center, PC /ID#200540 — Phoenix
- Arizona Research Center, Inc. /ID# 200546 — Phoenix
- Clear Dermatology & Aesthetics Center /ID# 201257 — Scottsdale
- University of Arizona /ID# 201059 — Tucson
Colorado
- Duplicate_University of Colorado Anchutz Medical Campus /ID# 202822 — Aurora
- Colorado Center for Dermatology, PLLC /ID# 203626 — Centennial
- Duplicate_Western States Clinical Research, Inc. /ID# 201702 — Wheat Ridge
Florida
- Clearlyderm Dermatology /ID# 207709 — Boca Raton
- Skin Care Research, LLC /ID# 200812 — Boca Raton
- Clinical Research of West Florida, Inc /ID# 203643 — Clearwater
Connecticut
- Dermatology Physicians of Connecticut /ID# 201004 — Shelton
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,533 participants |
| Start Date | 2018-08-09 |
| Est. Completion | 2030-10-23 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03568318
The ClinicalTrials.gov registry entry for NCT03568318 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 1,533 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is AbbVie, which has 603 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Atopic Dermatitis appearing as the primary indexed condition, and to 3 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT03568318 reports 20 study locations spanning 6 distinct geographic areas — top geographies include California, Alabama, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT03568318 about?
NCT03568318 is a clinical study titled "A Study to Evaluate Upadacitinib in Combination With Topical Corticosteroids in Adolescent and Adult Participants With Moderate to Severe Atopic Dermatitis". The objective of this study is to assess the efficacy and safety of upadacitinib combined with topical corticosteroids (TCS) for the treatment of adolescent and adult participants with moderate to severe atopic dermatitis (AD) who are candidates for systemic therapy.
What is the current status of trial NCT03568318?
This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 1,533 participants. The study started on 2018-08-09. Estimated completion is 2030-10-23.
What conditions does trial NCT03568318 study?
This clinical trial studies the following conditions: Atopic Dermatitis. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT03568318?
The interventions under investigation include: Placebo (DRUG), Upadacitinib (DRUG), Topical corticosteroids (TCS) (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT03568318?
This trial is sponsored by AbbVie, which has 603 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT03568318 being conducted?
This trial has 20 study locations across Alabama, Arizona, California, Colorado, Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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