Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT03492307 · ClinicalTrials.gov registry record · NA
Weight-based Flow Rates for Children With Bronchiolitis on High-Flow Nasal Cannula: A Pilot Randomized Control Trial
A NA study of Bronchiolitis, sponsored by Boston Children's Hospital.
- Completed
- Registry status
- NA
- Development phase
- 60
- Enrollment target
- 1
- Study location
NCT03492307: Completed NA study of Bronchiolitis, sponsored by Boston Children's Hospital.
NCT03492307 is a NA study of Bronchiolitis that has completed, run by Boston Children's Hospital. The registered enrollment target is 60 participants, below the 572-participant average among 12 other Bronchiolitis trials with a reported enrollment target (90% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03492307, a NA study of Bronchiolitis, has completed, sponsored by Boston Children's Hospital.
- COMPLETED
- Registry status
- NA
- Development phase
- 60 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a pilot study comparing a weight-based high-flow nasal cannula (HFNC) protocol with the current standard HFNC protocol for children \<2yo admitted to South Shore Hospital with bronchiolitis. We currently use a flat limit of 8 liters of HFNC to support work of breathing and hypoxia in these patients. We will compare that to a weight-based protocol, which will provide 2L/kg/min of flow (flows generally between 6 and 20L/minute) to this patient population. The goal of this pilot study is to assess the feasibility of our study design. We will evaluate the functionality of a new weight-based flow protocol. We will also evaluate the functionality of a new bronchiolitis scoring tool, the Bronchiolitis Assessment Severity Score (BASS), and it's ability to guide care through the new protocol. We are also testing the feasibility of recruitment, randomization and retention. We are ultimately interested in whether a weight-based flow protocol reduces need for escalation to ICU-level care for children with moderate-severe bronchiolitis on HFNC.
Primary Outcome
Need for escalation to NIV (CPAP or BIPAP) or intubation
Conditions Studied
Interventions
- OTHER Weight-Based Flow for High Flow Nasal Cannula (HFNC) (2L/kg/minute)
- OTHER Standard Flow for HFNC (Maximum 8L/minute)
Study Locations (1)
Massachusetts
- South Shore Hospital - Weymouth
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2018-05-01 |
| Est. Completion | 2020-03-30 |
| Phase | NA |
What the finished NCT03492307 record still lists
NCT03492307 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 572-participant average among 12 other Bronchiolitis trials with a reported enrollment target (90% lower).
The record links to 1 condition, with Bronchiolitis appearing as the primary indexed condition, and to 2 interventions - of which Weight-Based Flow for High Flow Nasal Cannula (HFNC) (2L/kg/minute) is the first listed.
NCT03492307 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT03492307 about?
NCT03492307 is a clinical study titled "Weight-based Flow Rates for Children With Bronchiolitis on High-Flow Nasal Cannula: A Pilot Randomized Control Trial". This is a pilot study comparing a weight-based high-flow nasal cannula (HFNC) protocol with the current standard HFNC protocol for children \<2yo admitted to South Shore Hospital with bronchiolitis. We currently use a flat limit of 8 liters of HFNC to support work of breathing and hypoxia in these p...
What is the current status of trial NCT03492307?
This trial is currently completed. It is a NA study. The enrollment target is 60 participants. The study started on 2018-05-01. Estimated completion is 2020-03-30.
What conditions does trial NCT03492307 study?
This clinical trial studies the following conditions: Bronchiolitis.
What interventions are being tested in trial NCT03492307?
The interventions under investigation include: Weight-Based Flow for High Flow Nasal Cannula (HFNC) (2L/kg/minute) (OTHER), Standard Flow for HFNC (Maximum 8L/minute) (OTHER).
Who is sponsoring clinical trial NCT03492307?
This trial is sponsored by Boston Children's Hospital, which has 462 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03492307 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Bronchiolitis
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03492307's enrollment target sits among peer trials
60 11th of 12 higher than 1 of 12 other Bronchiolitis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Bronchiolitis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Respiratory Support and Treatment for Efficient and Cost-Effective Care
RECRUITING · NA
-
Leveraging Electronic Health Record Tools to Improve the Evidence-Based Treatment of Children Hospitalized With Bronchiolitis
RECRUITING · NA
-
Non-Invasive Ventilation Versus Neurally-Adjusted Ventilatory Assistance (NAVA) for the Treatment of Bronchiolitis
RECRUITING · NA
-
Simultaneously Implementing Pathways for Improving Asthma, Pneumonia, and Bronchiolitis Care for Hospitalized Children
ACTIVE NOT RECRUITING · NA
-
A Study of Hypertonic Saline for Infants Hospitalized With Bronchiolitis
COMPLETED · NA
-
The Bronchiolitis Follow-up Intervention Trial
COMPLETED · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT00576069 · 60 participants
Mechanism(s)of Airflow Limitation in Moderate-severe Persistent Asthma
- NCT01297400 · 60 participants · Phase 2
Phase 2 Pilot Study of the Safety and Efficacy of Topical MW-III in Thermal Burns
- NCT01734122 · 60 participants
Stereotactic Radiosurgery for Essential Tremor and Parkinsonian Tremor
- NCT01804634 · 60 participants · Phase 2
Reduced Intensity Haploidentical BMT for High Risk Solid Tumors
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI