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NCT03435055 · ClinicalTrials.gov registry record · Phase 4
Network-Level Effects of Nitrous Oxide in the Human Brain
A Phase 4 study, sponsored by University of Michigan.
- Completed
- Registry status
- Phase 4
- Development phase
- 21
- Enrollment target
NCT03435055: Completed Phase 4 study, sponsored by University of Michigan.
NCT03435055 is a Phase 4 study that has completed, run by University of Michigan. The registered enrollment target is 21 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (96% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03435055, a Phase 4 study, has completed, sponsored by University of Michigan.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 21 participants
- Enrollment target
Study Summary
The purpose of this study is to understand how a commonly used drug, nitrous oxide, acts on the brain to reduce pain. Nitrous oxide is commonly used in anesthesiology but there is limited knowledge on how this drug affects functional networks in the brain.
Primary Outcome
Functional connectivity measures will be assessed at rest (baseline) and during sub anesthetic dose nitrous oxide (nitrous oxide). Seed-to-whole brain functional connectivity (Fisher's r-transformed z) will be measured from the left anterior insula, previously shown to be involved in pain and sensory processing. Paired t-test were conducted on subject specific beta maps to identify changes in connectivity associated with nitrous oxide in SPM12. The z-score descriptors represent the Fishers-r-to-
Interventions
- DRUG Nitrous Oxide Gas for Inhalation
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 21 participants |
| Start Date | 2017-07-21 |
| Est. Completion | 2019-10-11 |
| Phase | Phase 4 |
What the finished NCT03435055 record still lists
NCT03435055 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 21 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (96% lower).
The record links to 0 conditions, and to 1 intervention - of which Nitrous Oxide Gas for Inhalation is the first listed.
NCT03435055 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03435055 about?
NCT03435055 is a clinical study titled "Network-Level Effects of Nitrous Oxide in the Human Brain". The purpose of this study is to understand how a commonly used drug, nitrous oxide, acts on the brain to reduce pain. Nitrous oxide is commonly used in anesthesiology but there is limited knowledge on how this drug affects functional networks in the brain.
What is the current status of trial NCT03435055?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 21 participants. The study started on 2017-07-21. Estimated completion is 2019-10-11.
What interventions are being tested in trial NCT03435055?
The interventions under investigation include: Nitrous Oxide Gas for Inhalation (DRUG).
Who is sponsoring clinical trial NCT03435055?
This trial is sponsored by University of Michigan, which has 1,327 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03435055's enrollment target sits among peer trials
21 1742nd of 2000 higher than 248 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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