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NCT03382158 · ClinicalTrials.gov registry record
International PPB/DICER1 Registry
A clinical trial of Wilms Tumor and Pineoblastoma, sponsored by Children's Hospitals and Clinics of Minnesota.
- Recruiting
- Registry status
- 3,400
- Enrollment target
- 1
- Study location
NCT03382158: Recruiting study of Wilms Tumor and Pineoblastoma, sponsored by Children's Hospitals and Clinics of Minnesota.
NCT03382158 is a study of Wilms Tumor and Pineoblastoma that is actively recruiting participants, run by Children's Hospitals and Clinics of Minnesota. The registered enrollment target is 3,400 participants, above the 50-participant average among 14 other Wilms Tumor trials with a reported enrollment target (6700% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03382158, a study of Wilms Tumor and Pineoblastoma, is actively recruiting participants, sponsored by Children's Hospitals and Clinics of Minnesota.
- RECRUITING
- Registry status
- 3,400 participants
- Enrollment target
- 1
- Study location
Study Summary
Pleuropulmonary blastoma (PPB) is a rare malignant neoplasm of the lung presenting in early childhood. Type I PPB is a purely cystic lesion, Type II is a partially cystic, partially solid tumor, Type III is a completely solid tumor. Treatment of children with PPB is at the discretion of the treating institution. This study builds off of the 2009 study and will also seek to enroll individuals with DICER1-associated conditions, some of whom may present only with the DICER1 gene mutation, which will help the Registry understand how these tumors and conditions develop, their clinical course and the most effective treatments.
Primary Outcome
The primary endpoint for statistical analysis will be time from start treatment to an event, defined as the occurrence of progression or recurrence of PPB, occurrence of a second malignant neoplasm, or death from any cause that is at least possibly related to the original disease or treatment.
Conditions Studied
Study Locations (1)
Minnesota
- Children's Minnesota - Minneapolis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 3,400 participants |
| Start Date | 2016-12-06 |
| Est. Completion | 2035-12-06 |
What NCT03382158 shows while recruiting
NCT03382158 is an observational study that tracks outcomes without assigning an intervention. Its 3,400 participants enrollment target places it among the larger protocols in the corpus, above the 50-participant average among 14 other Wilms Tumor trials with a reported enrollment target (6700% higher).
The record links to 10 conditions, with Wilms Tumor appearing as the primary indexed condition, and to 0 interventions.
NCT03382158 reports a single indexed study location in Minnesota.
Frequently Asked Questions
What is clinical trial NCT03382158 about?
NCT03382158 is a clinical study titled "International PPB/DICER1 Registry". Pleuropulmonary blastoma (PPB) is a rare malignant neoplasm of the lung presenting in early childhood. Type I PPB is a purely cystic lesion, Type II is a partially cystic, partially solid tumor, Type III is a completely solid tumor. Treatment of children with PPB is at the discretion of the treating...
What is the current status of trial NCT03382158?
This trial is currently recruiting. The enrollment target is 3,400 participants. The study started on 2016-12-06. Estimated completion is 2035-12-06.
What conditions does trial NCT03382158 study?
This clinical trial studies the following conditions: Wilms Tumor, Pineoblastoma, Pleuropulmonary Blastoma, DICER1 Syndrome, Cystic Nephroma.
Who is sponsoring clinical trial NCT03382158?
This trial is sponsored by Children's Hospitals and Clinics of Minnesota, which has 31 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03382158 being conducted?
This trial has 1 study location across Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT03382158's enrollment target sits among peer trials
3,400 1st of 14 higher than 14 of 14 other Wilms Tumor trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Wilms Tumor trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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