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NCT03335332 · ClinicalTrials.gov registry record · NA
High Intensity Exercise for Increasing Fitness in Patients With Hypertrophic Cardiomyopathy
A NA study, sponsored by University of Texas Southwestern Medical Center.
- Completed
- Registry status
- NA
- Development phase
- 29
- Enrollment target
NCT03335332: Completed NA study, sponsored by University of Texas Southwestern Medical Center.
NCT03335332 is a NA study that has completed, run by University of Texas Southwestern Medical Center. The registered enrollment target is 29 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03335332, a NA study, has completed, sponsored by University of Texas Southwestern Medical Center.
- COMPLETED
- Registry status
- NA
- Development phase
- 29 participants
- Enrollment target
Study Summary
Although current clinical guidelines stipulate that patients with hypertrophic cardiomyopathy should not partake in high intensity exercise (HIE) or competitive sport due to safety concerns, there is no clear evidence to support this notion. In fact, two exercise training interventions in this population indicates that regular moderate to vigorous intensity exercise is efficacious for improving exercise capacity and cardiorespiratory fitness, and does not increase arrhythmia burden or adverse events. Moreover, moderate intensity exercise and HIE training significantly increases cardiorespiratory fitness in patients with cardiac disease. Such improvements are associated with substantial reductions in cardiovascular mortality and might outweigh the risk of adverse events in patients with hypertrophic cardiomyopathy (HCM). Having a genetic cardiomyopathy does not grant immunity against lifestyle related cardiometabolic diseases and inactivity is rife in HCM patients likely due to misinformation/education. It is therefore paramount to further explore the benefits of regular moderate intensity exercise and HIE in patients with HCM for proper therapeutic management of the condition.
Primary Outcome
Change in maximal oxygen uptake (V̇O2max)
Interventions
- BEHAVIORAL High intensity exercise
- BEHAVIORAL Moderate intensity exercise
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 29 participants |
| Start Date | 2018-01-31 |
| Est. Completion | 2022-12-20 |
| Phase | NA |
What the finished NCT03335332 record still lists
NCT03335332 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 29 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower).
The record links to 0 conditions, and to 2 interventions - of which High intensity exercise is the first listed.
NCT03335332 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03335332 about?
NCT03335332 is a clinical study titled "High Intensity Exercise for Increasing Fitness in Patients With Hypertrophic Cardiomyopathy". Although current clinical guidelines stipulate that patients with hypertrophic cardiomyopathy should not partake in high intensity exercise (HIE) or competitive sport due to safety concerns, there is no clear evidence to support this notion. In fact, two exercise training interventions in this popul...
What is the current status of trial NCT03335332?
This trial is currently completed. It is a NA study. The enrollment target is 29 participants. The study started on 2018-01-31. Estimated completion is 2022-12-20.
What interventions are being tested in trial NCT03335332?
The interventions under investigation include: High intensity exercise (BEHAVIORAL), Moderate intensity exercise (BEHAVIORAL).
Who is sponsoring clinical trial NCT03335332?
This trial is sponsored by University of Texas Southwestern Medical Center, which has 837 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03335332's enrollment target sits among peer trials
29 1702nd of 2000 higher than 297 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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