Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

COMPLETED Phase 2

A Study of Pembrolizumab Plus Epacadostat With Platinum-based Chemotherapy Versus Pembrolizumab Plus Platinum-based Chemotherapy Plus Placebo in Metastatic Non-Small Cell Lung Cancer (KEYNOTE-715-06/ECHO-306-06)

NCT03322566 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study was to evaluate the efficacy and safety of pembrolizumab plus epacadostat with platinum-based chemotherapy versus pembrolizumab plus platinum-based chemotherapy plus placebo as first-line therapy in participants with metastatic non-small cell lung cancer (NSCLC).

Conditions Studied

Interventions

  • DRUG Pembrolizumab
  • DRUG Placebo
  • DRUG Epacadostat
  • DRUG Platinum-based chemotherapy

Study Locations (20)

Florida

  • Lynn Cancer Institute — Boca Raton
  • Florida Cancer Specialists (South Region) — Fort Myers
  • Florida Cancer Specialists (North Region) — St. Petersburg

Arizona

  • Western Regional Medical Center, Inc. — Goodyear
  • Arizona Oncology Associates PC- HOPE — Tucson

Pennsylvania

  • St. Luke's Hospital - Anderson Campus — Easton
  • Allegheny General Hospital — Pittsburgh

Tennessee

  • Tennessee Oncology, PLLC/The Sarah Cannon Research Institute — Chattanooga
  • Tennessee Oncology, PLLC/The Sarah Cannon Research Institute — Nashville

Virginia

  • Oncology & Hematology Assoc. SW Virginia, Inc., DBA Blue Ridge Cancer Care — Blacksburg
  • Emily Couric Clinical Cancer Center — Charlottesville

Alabama

  • Southern Cancer Center, PC — Daphne

Indiana

  • PPG-Oncology — Fort Wayne

Michigan

  • University of Michigan — Ann Arbor

Trial Details

FieldValue
Enrollment Target 233 participants
Start Date 2018-01-09
Est. Completion 2020-10-16
Phase Phase 2

Sponsor

Incyte Corporation

163 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT03322566

The ClinicalTrials.gov registry entry for NCT03322566 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 233 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Incyte Corporation, which has 163 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Lung Cancer appearing as the primary indexed condition, and to 4 interventions — of which Pembrolizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT03322566 reports 20 study locations spanning 14 distinct geographic areas — top geographies include Florida, Arizona, Pennsylvania. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT03322566 about?

NCT03322566 is a clinical study titled "A Study of Pembrolizumab Plus Epacadostat With Platinum-based Chemotherapy Versus Pembrolizumab Plus Platinum-based Chemotherapy Plus Placebo in Metastatic Non-Small Cell Lung Cancer (KEYNOTE-715-06/ECHO-306-06)". The purpose of this study was to evaluate the efficacy and safety of pembrolizumab plus epacadostat with platinum-based chemotherapy versus pembrolizumab plus platinum-based chemotherapy plus placebo as first-line therapy in participants with metastatic non-small cell lung cancer (NSCLC).

What is the current status of trial NCT03322566?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 233 participants. The study started on 2018-01-09. Estimated completion is 2020-10-16.

What conditions does trial NCT03322566 study?

This clinical trial studies the following conditions: Lung Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT03322566?

The interventions under investigation include: Pembrolizumab (DRUG), Placebo (DRUG), Epacadostat (DRUG), Platinum-based chemotherapy (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT03322566?

This trial is sponsored by Incyte Corporation, which has 163 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT03322566 being conducted?

This trial has 20 study locations across Alabama, Arizona, Florida, Indiana, Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial