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NCT07141706 · ClinicalTrials.gov registry record · Phase 1

A Study of DB-1317 in Selected Advanced/Metastatic Solid Tumors

A Phase 1 study of Advanced/Metastatic Solid Tumors, sponsored by DualityBio.

Recruiting
Registry status
Phase 1
Development phase
233
Enrollment target
5
Study locations

NCT07141706 is a Phase 1 study of Advanced/Metastatic Solid Tumors that is actively recruiting participants, run by DualityBio. The registered enrollment target is 233 participants, below the 271-participant average among 4 other Advanced/Metastatic Solid Tumors trials with a reported enrollment target (14% lower). The trial reports 5 study locations across 4 states.

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The verdict

NCT07141706, a Phase 1 study of Advanced/Metastatic Solid Tumors, is actively recruiting participants, sponsored by DualityBio.

RECRUITING
Registry status
Phase 1
Development phase
233 participants
Enrollment target
5
Study locations

Study Summary

This is a multicenter, open-label, multiple-dose, FIH Phase 1a/1b study. Phase 1a adopts an accelerated titration design and a BOIN design to identify the MTD or MAD of DB-1317; Phase 1b includes up to 3 randomized dose expansion cohorts to further evaluate the safety, tolerability and preliminary efficacy of DB-1317 in selected solid tumors and to identify optimal RP2D.

Conditions Studied

Advanced/Metastatic Solid Tumors

Interventions

  • DRUG DB-1317

Study Locations (5)

Texas

  • USA02-0 - Houston
  • USA03-0 - San Antonio

California

  • USA04-0 - Los Angeles

Virginia

  • USA01 - Fairfax

New South Wales

  • AUS01-0 - Randwick

Trial Details

FieldValue
Enrollment Target 233 participants
Start Date 2025-09-23
Est. Completion 2028-06
Phase Phase 1

Sponsor

DualityBio

10 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07141706

The ClinicalTrials.gov registry entry for NCT07141706 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 233 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 271-participant average among 4 other Advanced/Metastatic Solid Tumors trials with a reported enrollment target (14% lower). The listed sponsor is DualityBio, which has 10 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Advanced/Metastatic Solid Tumors appearing as the primary indexed condition, and to 1 intervention - of which DB-1317 is the first listed.

NCT07141706 reports 5 study locations spanning 4 distinct geographic areas - top geographies include Texas, California, Virginia.

Frequently Asked Questions

What is clinical trial NCT07141706 about?

NCT07141706 is a clinical study titled "A Study of DB-1317 in Selected Advanced/Metastatic Solid Tumors". This is a multicenter, open-label, multiple-dose, FIH Phase 1a/1b study. Phase 1a adopts an accelerated titration design and a BOIN design to identify the MTD or MAD of DB-1317; Phase 1b includes up to 3 randomized dose expansion cohorts to further evaluate the safety, tolerability and preliminary e...

What is the current status of trial NCT07141706?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 233 participants. The study started on 2025-09-23. Estimated completion is 2028-06.

What conditions does trial NCT07141706 study?

This clinical trial studies the following conditions: Advanced/Metastatic Solid Tumors.

What interventions are being tested in trial NCT07141706?

The interventions under investigation include: DB-1317 (DRUG).

Who is sponsoring clinical trial NCT07141706?

This trial is sponsored by DualityBio, which has 10 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT07141706 being conducted?

This trial has 5 study locations across California, Texas, Virginia, New South Wales. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.