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RECRUITING Phase 2

Study of Novel Treatment Combinations in Patients With Lung Cancer

NCT05633667 · View on ClinicalTrials.gov ↗

Study Summary

The goal of this platform clinical trial is to test how well novel treatment combinations work in participants with lung cancer. Substudy-01 will compare the different novel combinations versus standard of care in participants with metastatic (cancer that has spread) non-small-cell lung cancer (NSCLC) who have not been treated before. Substudy-02 will compare the different novel combination versus standard of care in participants with cancer that has progressed after receiving previous treatment for metastatic NSCLC. Substudy-03 will compare the different novel combinations versus standard of care in participants with resectable stage II-III NSCLC. The primary objectives of this study are: Substudy-01 and Substudy-02: To evaluate the objective response rate (ORR) assessed per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST v1.1). Substudy-03: To evaluate the efficacy of treatment combinations based on complete pathological response (pCR) rate.

Interventions

  • DRUG Carboplatin
  • DRUG Zimberelimab (ZIM)
  • DRUG Domvanalimab (DOM)
  • DRUG Sacituzumab govitecan-hziy (SG)
  • DRUG Etrumadenant (ETRUMA)

Study Locations (20)

Missouri

  • Washington University School of Medicine - Siteman Cancer Center,Substudy-01 — St Louis
  • Washington University School of Medicine - Siteman Cancer Center,Substudy-02 — St Louis
  • Washington University School of Medicine - Siteman Cancer Center,Substudy-03 — St Louis
  • Washington University School of Medicine - Siteman Cancer Center — St Louis

Arizona

  • Arizona Oncology Associates,Substudy-01 — Tucson
  • Arizona Oncology Associates,Substudy-02 — Tucson

Colorado

  • Rocky Mountain Cancer Center,Substudy-01 — Denver
  • Rocky Mountain Cancer Center,Substudy-02 — Denver

Ohio

  • Oncology Hematology Care Clinical Trials, LLC,Substudy-01 — Cincinnati
  • Oncology Hematology Care Clinical Trials, LLC,Substudy-02 — Cincinnati

Oregon

  • Oncology Associates of Oregon, PC,Substudy-01 — Eugene
  • Oncology Associates of Oregon, PC,Substudy-02 — Eugene

Texas

  • Texas Oncology - Central South,Substudy-01 — Austin
  • Texas Oncology - Central South,Substudy-02 — Austin

Virginia

  • US Oncology Investigational Products Center (IPC),Substudy-01 — Fairfax
  • US Oncology Investigational Products Center (IPC),Substudy-02 — Fairfax

Washington

  • Fred Hutchinson Cancer Center,Substudy-01 — Seattle
  • Fred Hutchinson Cancer Center,Substudy-02 — Seattle

Trial Details

FieldValue
Enrollment Target 270 participants
Start Date 2023-03-16
Est. Completion 2029-09
Phase Phase 2

Sponsor

Gilead Sciences

190 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05633667

The ClinicalTrials.gov registry entry for NCT05633667 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 270 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Gilead Sciences, which has 190 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 3 conditions, with Lung Cancer appearing as the primary indexed condition, and to 5 interventions — of which Carboplatin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05633667 reports 20 study locations spanning 10 distinct geographic areas — top geographies include Missouri, Arizona, Colorado. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05633667 about?

NCT05633667 is a clinical study titled "Study of Novel Treatment Combinations in Patients With Lung Cancer". The goal of this platform clinical trial is to test how well novel treatment combinations work in participants with lung cancer. Substudy-01 will compare the different novel combinations versus standard of care in participants with metastatic (cancer that has spread) non-small-cell lung cancer (NSCL...

What is the current status of trial NCT05633667?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 270 participants. The study started on 2023-03-16. Estimated completion is 2029-09.

What conditions does trial NCT05633667 study?

This clinical trial studies the following conditions: Lung Cancer, Advanced or Metastatic Non-Small-Cell Lung Cancer, Resectable Non-Small-Cell Lung Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05633667?

The interventions under investigation include: Carboplatin (DRUG), Zimberelimab (ZIM) (DRUG), Domvanalimab (DOM) (DRUG), Sacituzumab govitecan-hziy (SG) (DRUG), Etrumadenant (ETRUMA) (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05633667?

This trial is sponsored by Gilead Sciences, which has 190 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05633667 being conducted?

This trial has 20 study locations across Arizona, Colorado, Indiana, Kentucky, Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial