Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT03300726 · ClinicalTrials.gov registry record
Synaptic Injury and Functional Connectivity in Alzheimer's Disease
A clinical trial of Alzheimer Disease, Late Onset, sponsored by Ohio State University.
- Completed
- Registry status
- 35
- Enrollment target
- 1
- Study location
NCT03300726: Completed study of Alzheimer Disease, Late Onset, sponsored by Ohio State University.
NCT03300726 is a study of Alzheimer Disease, Late Onset that has completed, run by Ohio State University. The registered enrollment target is 35 participants, below the 2,296-participant average among 7 other Alzheimer Disease, Late Onset trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03300726, a study of Alzheimer Disease, Late Onset, has completed, sponsored by Ohio State University.
- COMPLETED
- Registry status
- 35 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to examine cross-sectional associations between CSF markers of synaptic injury (Ng and SNAP-25) and functional connectivity in default and semantic memory networks using 3T- fMRI in individuals with MCI (i.e. the earliest clinically detectable stage of cognitive impairment) due to AD or mild AD dementia (CDR 0.5-1; n=20) and cognitively normal controls (CDR 0; n=20).
Primary Outcome
Cross-sectional associations between CSF biomarker measurements and fMRI measures at baseline
Conditions Studied
Interventions
- DIAGNOSTIC_TEST CSF analysis
- RADIATION Functional MRI
Study Locations (1)
Ohio
- The Ohio State University Wexner Medical Center - Columbus
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 35 participants |
| Start Date | 2018-02-12 |
| Est. Completion | 2021-09-22 |
What the finished NCT03300726 record still lists
NCT03300726 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 35 participants, a relatively small participant target, below the 2,296-participant average among 7 other Alzheimer Disease, Late Onset trials with a reported enrollment target (98% lower).
The record links to 1 condition, with Alzheimer Disease, Late Onset appearing as the primary indexed condition, and to 2 interventions - of which CSF analysis is the first listed.
NCT03300726 reports a single indexed study location in Ohio.
Frequently Asked Questions
What is clinical trial NCT03300726 about?
NCT03300726 is a clinical study titled "Synaptic Injury and Functional Connectivity in Alzheimer's Disease". The purpose of this study is to examine cross-sectional associations between CSF markers of synaptic injury (Ng and SNAP-25) and functional connectivity in default and semantic memory networks using 3T- fMRI in individuals with MCI (i.e. the earliest clinically detectable stage of cognitive impairme...
What is the current status of trial NCT03300726?
This trial is currently completed. The enrollment target is 35 participants. The study started on 2018-02-12. Estimated completion is 2021-09-22.
What conditions does trial NCT03300726 study?
This clinical trial studies the following conditions: Alzheimer Disease, Late Onset.
What interventions are being tested in trial NCT03300726?
The interventions under investigation include: CSF analysis (DIAGNOSTIC_TEST), Functional MRI (RADIATION).
Who is sponsoring clinical trial NCT03300726?
This trial is sponsored by Ohio State University, which has 552 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03300726 being conducted?
This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Alzheimer Disease, Late Onset
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
-
NYSCF Scientific Discovery Biobank
RECRUITING
-
Time-in-bed Restriction in Older Adults With Sleep Difficulties With and Without Risk for Alzheimer's Disease
RECRUITING · Early Phase 1
-
Chronic Treatment of Alzheimer's Disease by Gamma Light and Sound Therapy
RECRUITING · NA
-
Reducing Risk of Dementia Through Deprescribing
ACTIVE NOT RECRUITING · NA
-
A Pivotal Study of Sensory Stimulation in Alzheimer's Disease (Hope Study, CA-0011)
ACTIVE NOT RECRUITING · NA
-
Safety and Efficacy of Transcranial Electromagnetic Treatment Against Alzheimer's Disease
COMPLETED · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01697371 · 35 participants · NA
Proton Therapy in the Treatment of Liver Metastases
- NCT01940757 · 35 participants · Phase 1
Experimental Infection of Hookworm-naïve Adults With Dermally-applied Infectious Necator Americanus Hookworm Larvae
- NCT02235857 · 35 participants · NA
Post Approval Study of Liposorber LA-15 System for the Treatment of Focal Segmental Glomerulosclerosis in Children
- NCT02637934 · 35 participants · Phase 1
Phase I Pilot Study of Biodistribution, Metabolism and Excretion of Novel Radiotracer [18F]Fluorthanatrace (FTT) by PET/CT
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI