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NCT04270474 · ClinicalTrials.gov registry record · NA
Reducing Risk of Dementia Through Deprescribing
A NA study of Dementia and Alzheimer Disease, Late Onset, sponsored by Indiana University.
- Active
- Registry status
- NA
- Development phase
- 344
- Enrollment target
- 2
- Study locations
NCT04270474: Active NA study of Dementia and Alzheimer Disease, Late Onset, sponsored by Indiana University.
NCT04270474 is a NA study of Dementia and Alzheimer Disease, Late Onset that is active but no longer recruiting, run by Indiana University. The registered enrollment target is 344 participants, below the 7,721-participant average among 199 other Dementia trials with a reported enrollment target (96% lower). The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04270474, a NA study of Dementia and Alzheimer Disease, Late Onset, is active but no longer recruiting, sponsored by Indiana University.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 344 participants
- Enrollment target
- 2
- Study locations
Study Summary
A cluster-randomized controlled trial (RCT) called "Reducing Risk of Dementia through Deprescribing" (R2D2) to evaluate the impact of a deprescribing intervention on important cognitive and safety outcomes.
Primary Outcome
Cognitive composite scores will be collected from participants at baseline, 6, 12, 18 and 24 months and changes in the composite scores over time will be compared between the intervention and usual care groups. An overall cognitive composite score including measures of information processing speed, memory, and executive function will be conducted at each time point from the average of each measure's z-score, constructed by subtracting the mean baseline scores and dividing by the baseline standar
Conditions Studied
Interventions
- OTHER Usual Care
- OTHER Deprescribing of target anticholinergics
Study Locations (2)
Indiana
- Indiana University Health - Indianapolis
- Community Health Network Foundation, Inc. - Indianapolis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 344 participants |
| Start Date | 2020-07-20 |
| Est. Completion | 2026-07-30 |
| Phase | NA |
What the registry record for NCT04270474 still lists
NCT04270474 is an interventional study that assigns participants to a tested intervention. The registered 344 participants enrollment target is mid-sized for trials with a published cap, below the 7,721-participant average among 199 other Dementia trials with a reported enrollment target (96% lower).
The record links to 2 conditions, with Dementia appearing as the primary indexed condition, and to 2 interventions - of which Usual Care is the first listed.
NCT04270474 reports a single indexed study location in Indiana.
Frequently Asked Questions
What is clinical trial NCT04270474 about?
NCT04270474 is a clinical study titled "Reducing Risk of Dementia Through Deprescribing". A cluster-randomized controlled trial (RCT) called "Reducing Risk of Dementia through Deprescribing" (R2D2) to evaluate the impact of a deprescribing intervention on important cognitive and safety outcomes.
What is the current status of trial NCT04270474?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 344 participants. The study started on 2020-07-20. Estimated completion is 2026-07-30.
What conditions does trial NCT04270474 study?
This clinical trial studies the following conditions: Dementia, Alzheimer Disease, Late Onset.
What interventions are being tested in trial NCT04270474?
The interventions under investigation include: Usual Care (OTHER), Deprescribing of target anticholinergics (OTHER).
Who is sponsoring clinical trial NCT04270474?
This trial is sponsored by Indiana University, which has 890 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04270474 being conducted?
This trial has 2 study locations across Indiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Dementia
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04270474's enrollment target sits among peer trials
344 66th of 199 higher than 134 of 199 other Dementia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Dementia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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