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ACTIVE NOT RECRUITING Phase 1

Atezolizumab, Pemetrexed Disodium, Cisplatin, and Surgery With or Without Radiation Therapy in Treating Patients With Stage I-III Pleural Malignant Mesothelioma

NCT03228537 · View on ClinicalTrials.gov ↗

Study Summary

This phase I pilot trial studies how well atezolizumab, pemetrexed disodium, cisplatin, and surgery with or without radiation therapy works in treating patients with stage I-III pleural malignant mesothelioma. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Pemetrexed disodium may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving atezolizumab, pemetrexed disodium, and cisplatin before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. Giving atezolizumab after surgery may kill any remaining tumor cells.

Interventions

  • DRUG Atezolizumab
  • DRUG Cisplatin
  • DRUG Pemetrexed Disodium
  • PROCEDURE Extrapleural Pneumonectomy
  • PROCEDURE Pleurectomy

Study Locations (20)

Colorado

  • Penrose-Saint Francis Healthcare — Colorado Springs
  • Rocky Mountain Cancer Centers-Penrose — Colorado Springs
  • AdventHealth Porter — Denver
  • CommonSpirit Cancer Center Mercy — Durango
  • Mercy Medical Center — Durango
  • Mountain Blue Cancer Care Center — Golden
  • Rocky Mountain Cancer Centers-Lakewood — Lakewood
  • Saint Anthony Hospital — Lakewood
  • AdventHealth Littleton — Littleton
  • Longmont United Hospital — Longmont
  • Rocky Mountain Cancer Centers-Longmont — Longmont
  • AdventHealth Parker — Parker
  • Rocky Mountain Cancer Centers-Parker — Parker
  • Saint Mary Corwin Medical Center — Pueblo

California

  • PCR Oncology — Arroyo Grande
  • City of Hope Comprehensive Cancer Center — Duarte
  • University of California Davis Comprehensive Cancer Center — Sacramento

Arizona

  • Mayo Clinic Hospital in Arizona — Phoenix
  • Mayo Clinic in Arizona — Scottsdale

Arkansas

  • CHI Saint Vincent Cancer Center Hot Springs — Hot Springs

Trial Details

FieldValue
Enrollment Target 28 participants
Start Date 2018-07-16
Est. Completion 2026-09-18
Phase Phase 1

Sponsor

National Cancer Institute (NCI)

2,390 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT03228537

The ClinicalTrials.gov registry entry for NCT03228537 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 28 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is National Cancer Institute (NCI), which has 2,390 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 7 conditions, with Epithelioid Mesothelioma appearing as the primary indexed condition, and to 5 interventions — of which Atezolizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT03228537 reports 20 study locations spanning 4 distinct geographic areas — top geographies include Colorado, California, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT03228537 about?

NCT03228537 is a clinical study titled "Atezolizumab, Pemetrexed Disodium, Cisplatin, and Surgery With or Without Radiation Therapy in Treating Patients With Stage I-III Pleural Malignant Mesothelioma". This phase I pilot trial studies how well atezolizumab, pemetrexed disodium, cisplatin, and surgery with or without radiation therapy works in treating patients with stage I-III pleural malignant mesothelioma. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune...

What is the current status of trial NCT03228537?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 28 participants. The study started on 2018-07-16. Estimated completion is 2026-09-18.

What conditions does trial NCT03228537 study?

This clinical trial studies the following conditions: Epithelioid Mesothelioma, Biphasic Mesothelioma, Stage I Pleural Malignant Mesothelioma AJCC v7, Stage IA Pleural Malignant Mesothelioma AJCC v7, Stage IB Pleural Malignant Mesothelioma AJCC v7. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT03228537?

The interventions under investigation include: Atezolizumab (DRUG), Cisplatin (DRUG), Pemetrexed Disodium (DRUG), Extrapleural Pneumonectomy (PROCEDURE), Pleurectomy (PROCEDURE). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT03228537?

This trial is sponsored by National Cancer Institute (NCI), which has 2,390 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT03228537 being conducted?

This trial has 20 study locations across Arizona, Arkansas, California, Colorado. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial