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NCT03178552 · ClinicalTrials.gov registry record · Phase 2
A Study to Evaluate the Efficacy and Safety of Multiple Targeted Therapies as Treatments for Participants With Non-Small Cell Lung Cancer (NSCLC)
A Phase 2 study of Non-Small Cell Lung Cancer, sponsored by Hoffmann-La Roche.
- Active
- Registry status
- Phase 2
- Development phase
- 1,000
- Enrollment target
- 20
- Study locations
NCT03178552: Active Phase 2 study of Non-Small Cell Lung Cancer, sponsored by Hoffmann-La Roche.
NCT03178552 is a Phase 2 study of Non-Small Cell Lung Cancer that is active but no longer recruiting, run by Hoffmann-La Roche. The registered enrollment target is 1,000 participants, above the 650-participant average among 454 other Non-Small Cell Lung Cancer trials with a reported enrollment target (54% higher). The trial reports 20 study locations across 14 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03178552, a Phase 2 study of Non-Small Cell Lung Cancer, is active but no longer recruiting, sponsored by Hoffmann-La Roche.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 2
- Development phase
- 1,000 participants
- Enrollment target
- 20
- Study locations
Study Summary
This is a phase 2/3, global, multicenter, open-label, multi-cohort study designed to evaluate the safety and efficacy of targeted therapies or immunotherapy as single agents or in combination in participants with unresectable, advanced or metastatic NSCLC determined to harbor oncogenic somatic mutations or positive by tumor mutational burden (TMB) assay as identified by a blood-based next-generation sequencing (NGS) circulating tumor DNA (ctDNA) assay.
Conditions Studied
Interventions
- DRUG Carboplatin
- DRUG Atezolizumab
- DRUG Cisplatin
- DRUG Pemetrexed
- DRUG Alectinib
Study Locations (20)
Other
- Fundación CENIT para la Investigación en Neurociencias - Buenos Aires
- Hospital Italiano - Buenos Aires
- Hospital Britanico de Buenos Aires - Ciudad Autonoma Buenos Aires
- UZ Brussel - Brussels
- Cliniques Universitaires St-Luc - Brussels
Florida
- SCRI Florida Cancer Specialists South - Fort Myers
- Florida Cancer Specialist, North Region - St. Petersburg
New York
- Weill Cornell Medical College-New York Presbyterian Hospital - New York
- Montefiore Medical Center - The Bronx
California
- UC Davis - Sacramento
Colorado
- Rocky Mountain Cancer Center - Denver
Kentucky
- University of Kentucky - Lexington
Nevada
- Comprehensive Cancer Centers of Nevada - Las Vegas
New Hampshire
- Dartmouth Hitchcock Medical Center - Lebanon
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,000 participants |
| Start Date | 2017-09-22 |
| Est. Completion | 2026-10-31 |
| Phase | Phase 2 |
What the registry record for NCT03178552 still lists
NCT03178552 is an interventional study that assigns participants to a tested intervention. Its 1,000 participants enrollment target places it among the larger protocols in the corpus, above the 650-participant average among 454 other Non-Small Cell Lung Cancer trials with a reported enrollment target (54% higher).
The record links to 1 condition, with Non-Small Cell Lung Cancer appearing as the primary indexed condition, and to 5 interventions - of which Carboplatin is the first listed.
NCT03178552 names 20 study sites across 14 states, led by Other, Florida, New York.
Frequently Asked Questions
What is clinical trial NCT03178552 about?
NCT03178552 is a clinical study titled "A Study to Evaluate the Efficacy and Safety of Multiple Targeted Therapies as Treatments for Participants With Non-Small Cell Lung Cancer (NSCLC)". This is a phase 2/3, global, multicenter, open-label, multi-cohort study designed to evaluate the safety and efficacy of targeted therapies or immunotherapy as single agents or in combination in participants with unresectable, advanced or metastatic NSCLC determined to harbor oncogenic somatic mutat...
What is the current status of trial NCT03178552?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 1,000 participants. The study started on 2017-09-22. Estimated completion is 2026-10-31.
What conditions does trial NCT03178552 study?
This clinical trial studies the following conditions: Non-Small Cell Lung Cancer.
What interventions are being tested in trial NCT03178552?
The interventions under investigation include: Carboplatin (DRUG), Atezolizumab (DRUG), Cisplatin (DRUG), Pemetrexed (DRUG), Alectinib (DRUG).
Who is sponsoring clinical trial NCT03178552?
This trial is sponsored by Hoffmann-La Roche, which has 909 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03178552 being conducted?
This trial has 20 study locations across California, Colorado, Florida, Kentucky, Nevada. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Non-Small Cell Lung Cancer
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03178552's enrollment target sits among peer trials
1,000 22nd of 454 higher than 432 of 454 other Non-Small Cell Lung Cancer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Non-Small Cell Lung Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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