Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT03111875 · ClinicalTrials.gov registry record · NA
Perioperative Hypothermia and Myocardial Injury After Non-cardiac Surgery
A NA study, sponsored by The Cleveland Clinic.
- Completed
- Registry status
- NA
- Development phase
- 5,056
- Enrollment target
NCT03111875: Completed NA study, sponsored by The Cleveland Clinic.
NCT03111875 is a NA study that has completed, run by The Cleveland Clinic. The registered enrollment target is 5,056 participants, above the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (260% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03111875, a NA study, has completed, sponsored by The Cleveland Clinic.
- COMPLETED
- Registry status
- NA
- Development phase
- 5,056 participants
- Enrollment target
Study Summary
We propose to test the hypothesis that aggressive warming reduces the incidence of major cardiovascular complications, compared to routine care. Half of the participants will be randomly assigned to routine care (core temperature ≈35.5°C), while the other half will receive aggressive warming (\>37°C core temperature) in a multi-center trial.
Primary Outcome
The primary outcome was a composite of myocardial injury after non-cardiac surgery, non-fatal cardiac arrest, and all-cause mortality within 30 days of surgery. Myocardial injury was diagnosed when available troponin concentrations exceeded generation-specific and type-specific thresholds and were apparently of ischaemic origin (ie, no other obvious cause for artifactual elevation). We used the following thresholds based on available literature at time of adjudication: 1) non-high-sensitivity (f
Interventions
- DEVICE aggressive warming
- DEVICE routine thermal management
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 5,056 participants |
| Start Date | 2017-03-27 |
| Est. Completion | 2022-05-17 |
| Phase | NA |
What the finished NCT03111875 record still lists
NCT03111875 is an interventional study that assigns participants to a tested intervention. Its 5,056 participants enrollment target places it among the larger protocols in the corpus, above the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (260% higher).
The record links to 0 conditions, and to 2 interventions - of which aggressive warming is the first listed.
NCT03111875 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03111875 about?
NCT03111875 is a clinical study titled "Perioperative Hypothermia and Myocardial Injury After Non-cardiac Surgery". We propose to test the hypothesis that aggressive warming reduces the incidence of major cardiovascular complications, compared to routine care. Half of the participants will be randomly assigned to routine care (core temperature ≈35.5°C), while the other half will receive aggressive warming (\>37°C...
What is the current status of trial NCT03111875?
This trial is currently completed. It is a NA study. The enrollment target is 5,056 participants. The study started on 2017-03-27. Estimated completion is 2022-05-17.
What interventions are being tested in trial NCT03111875?
The interventions under investigation include: aggressive warming (DEVICE), routine thermal management (DEVICE).
Who is sponsoring clinical trial NCT03111875?
This trial is sponsored by The Cleveland Clinic, which has 688 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03111875's enrollment target sits among peer trials
5,056 25th of 2000 higher than 1,976 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT07037459 · 5,056 participants · Phase 3
Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
- NCT06292078 · 5,076 participants · NA
Preventing School Exclusion and Opioid Misuse: Effectiveness of the Inclusive Skill-building Learning Approach (ISLA)
- NCT05018611 · 5,100 participants · NA
Digital Limited Interaction Efficacy Trial of LifeSkills Mobile to Reduce HIV Incidence in YTW
- NCT05701358 · 5,100 participants · NA
Physiology-guided vs Angiography-guided Non-culprit Lesion Complete Revascularization for Acute MI & Multivessel Disease
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI