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NCT03083132 · ClinicalTrials.gov registry record · Phase 2
Modafinil for Freezing of Gait (FOG) in Parkinson's Disease (PD)
A Phase 2 study, sponsored by University of Arkansas.
- Completed
- Registry status
- Phase 2
- Development phase
- 21
- Enrollment target
NCT03083132: Completed Phase 2 study, sponsored by University of Arkansas.
NCT03083132 is a Phase 2 study that has completed, run by University of Arkansas. The registered enrollment target is 21 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (84% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03083132, a Phase 2 study, has completed, sponsored by University of Arkansas.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 21 participants
- Enrollment target
Study Summary
Freezing of gait is a late stage complication of Parkinson's disease in which patients note that their feet feel stuck or glued to the ground. This can lead to imbalance and falls and the secondary complications that can result from falls such as fractures and hospitalizations. While levodopa can help freezing of gait in some patients, it does not help in all, and the dose needed to treat freezing may be limited by side effects of the medications. Currently there are no treatments targeted towards freezing of gait and the goal of this research is to see if Modafinil could be one such drug to help freezing of gait in Parkinson's disease.
Primary Outcome
The freezing of gait questionnaire (FOG-Q) was administered by a movement disorders neurologist at baseline (week 0), and again after taking the randomly assigned treatment (either Modafinil or placebo) for 12 weeks. The FOG-Q scores 6 items between 0 and 4, for a total score of 24; higher values indicate worse FOG.
Interventions
- DRUG Placebo oral capsule
- DRUG modafinil 50mg
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 21 participants |
| Start Date | 2017-06-13 |
| Est. Completion | 2019-11-12 |
| Phase | Phase 2 |
What the finished NCT03083132 record still lists
NCT03083132 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 21 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (84% lower).
The record links to 0 conditions, and to 2 interventions - of which Placebo oral capsule is the first listed.
NCT03083132 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03083132 about?
NCT03083132 is a clinical study titled "Modafinil for Freezing of Gait (FOG) in Parkinson's Disease (PD)". Freezing of gait is a late stage complication of Parkinson's disease in which patients note that their feet feel stuck or glued to the ground. This can lead to imbalance and falls and the secondary complications that can result from falls such as fractures and hospitalizations. While levodopa can he...
What is the current status of trial NCT03083132?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 21 participants. The study started on 2017-06-13. Estimated completion is 2019-11-12.
What interventions are being tested in trial NCT03083132?
The interventions under investigation include: Placebo oral capsule (DRUG), modafinil 50mg (DRUG).
Who is sponsoring clinical trial NCT03083132?
This trial is sponsored by University of Arkansas, which has 318 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03083132's enrollment target sits among peer trials
21 1794th of 2000 higher than 196 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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