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NCT02399475 · ClinicalTrials.gov registry record · NA
Mechanistic Study of Subclinical Hypothyroidism In the Elderly
A NA study of Subclinical Hypothyroidism, sponsored by University of Pennsylvania.
- Completed
- Registry status
- NA
- Development phase
- 14
- Enrollment target
- 1
- Study location
NCT02399475: Completed NA study of Subclinical Hypothyroidism, sponsored by University of Pennsylvania.
NCT02399475 is a NA study of Subclinical Hypothyroidism that has completed, run by University of Pennsylvania. The registered enrollment target is 14 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02399475, a NA study of Subclinical Hypothyroidism, has completed, sponsored by University of Pennsylvania.
- COMPLETED
- Registry status
- NA
- Development phase
- 14 participants
- Enrollment target
- 1
- Study location
Study Summary
Subclinical hypothyroidism, defined as an elevated TSH in the setting of normal thyroid hormone levels, is a common diagnosis in the elderly. The purpose of this study is to examine the hypothalamic-pituitary-thyroid axis in men and women aged 70 years and older with persistent subclinical hypothyroidism. To evaluate the mechanism behind this condition, participants will undergo thyrotropin releasing hormone stimulation testing at 3 visits: baseline and while taking two different thyroid hormone preparations, levothyroxine and liothyronine. The investigators will also assess physiologic responses to these two different thyroid hormone medications to help us understand how the thyroid works in advanced age.
Primary Outcome
TSH area under the curve within 60 minutes of TRH stimulation when TSH is at goal
Conditions Studied
Interventions
- DRUG Levothyroxine
- DRUG Liothyronine
- DRUG Thyrotropin-Releasing Hormone
Study Locations (1)
Pennsylvania
- University of Pennsylvania - Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 14 participants |
| Start Date | 2015-01-01 |
| Est. Completion | 2019-09-30 |
| Phase | NA |
What the finished NCT02399475 record still lists
NCT02399475 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 14 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 1 condition, with Subclinical Hypothyroidism appearing as the primary indexed condition, and to 3 interventions - of which Levothyroxine is the first listed.
NCT02399475 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT02399475 about?
NCT02399475 is a clinical study titled "Mechanistic Study of Subclinical Hypothyroidism In the Elderly". Subclinical hypothyroidism, defined as an elevated TSH in the setting of normal thyroid hormone levels, is a common diagnosis in the elderly. The purpose of this study is to examine the hypothalamic-pituitary-thyroid axis in men and women aged 70 years and older with persistent subclinical hypothyro...
What is the current status of trial NCT02399475?
This trial is currently completed. It is a NA study. The enrollment target is 14 participants. The study started on 2015-01-01. Estimated completion is 2019-09-30.
What conditions does trial NCT02399475 study?
This clinical trial studies the following conditions: Subclinical Hypothyroidism.
What interventions are being tested in trial NCT02399475?
The interventions under investigation include: Levothyroxine (DRUG), Liothyronine (DRUG), Thyrotropin-Releasing Hormone (DRUG).
Who is sponsoring clinical trial NCT02399475?
This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02399475 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT02399475's enrollment target sits among peer trials
14 1909th of 2000 higher than 90 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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