Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
A Study of Intravenous (IV) Cergutuzumab Amunaleukin and Atezolizumab in Combination in Participants With Locally Advanced and/or Metastatic Solid Tumors
NCT02350673 · View on ClinicalTrials.gov ↗
Study Summary
This is an open-label, multi-center, Phase Ib clinical study of cergutuzumab amunaleukin, in combination with atezolizumab, to investigate the safety, pharmacokinetics, and therapeutic activity in participants with locally advanced and/or metastatic carcinoembryonic antigen (CEA)-positive solid tumors, whose disease has progressed on or who are intolerant to the standard of care therapy. Enrolled participants who continue treatment will be treated until loss of clinical benefit, unacceptable toxicities, or withdrawal of consent. The study will include 2 parts: a dose-escalation Part I and a dose expansion Part II. The anticipated treatment period is 24 months for both cergutuzumab amunaleukin and atezolizumab and may be modified if emerging data suggest a benefit.
Conditions Studied
Interventions
- DRUG Atezolizumab
- DRUG Cergutuzumab Amunaleukin
Study Locations (14)
Other
- Herlev Hospital; Onkologisk afdeling — Herlev
- Rigshospitalet; Onkologisk Klinik — København Ø
- Antoni van Leeuwenhoek Ziekenhuis — Amsterdam
- Erasmus MC — Rotterdam
- Hospital Univ Vall d'Hebron; Servicio de Oncologia — Barcelona
- START Madrid. Centro Integral Oncologico Clara Campal; CIOCC — Madrid
- Hospital Clinico Universitario de Valencia; Servicio de Onco-hematologia — Valencia
- CHUV; Departement d'Oncologie — Lausanne
New York
- Columbia Univ Med Ctr — New York
- Memorial Sloan Kettering Cancer Center — New York
Connecticut
- Yale Cancer Center; Medical Oncology — New Haven
Tennessee
- SCRI-Tennessee Oncology — Nashville
Ontario
- University Health Network; Princess Margaret Hospital; Medical Oncology Dept — Toronto
Navarre
- Clinica Universitaria de Navarra; Servicio de oncología — Pamplona
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 70 participants |
| Start Date | 2015-06-29 |
| Est. Completion | 2019-12-16 |
| Phase | Phase 1 |
Interested in This Trial?
Always speak with your doctor before enrolling in a clinical trial.
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02350673
The ClinicalTrials.gov registry entry for NCT02350673 describes a study currently listed as completed. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 70 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Hoffmann-La Roche, which has 758 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Solid Tumors appearing as the primary indexed condition, and to 2 interventions — of which Atezolizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT02350673 reports 14 study locations spanning 6 distinct geographic areas — top geographies include Other, New York, Connecticut. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT02350673 about?
NCT02350673 is a clinical study titled "A Study of Intravenous (IV) Cergutuzumab Amunaleukin and Atezolizumab in Combination in Participants With Locally Advanced and/or Metastatic Solid Tumors". This is an open-label, multi-center, Phase Ib clinical study of cergutuzumab amunaleukin, in combination with atezolizumab, to investigate the safety, pharmacokinetics, and therapeutic activity in participants with locally advanced and/or metastatic carcinoembryonic antigen (CEA)-positive solid tumo...
What is the current status of trial NCT02350673?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 70 participants. The study started on 2015-06-29. Estimated completion is 2019-12-16.
What conditions does trial NCT02350673 study?
This clinical trial studies the following conditions: Solid Tumors. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT02350673?
The interventions under investigation include: Atezolizumab (DRUG), Cergutuzumab Amunaleukin (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT02350673?
This trial is sponsored by Hoffmann-La Roche, which has 758 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT02350673 being conducted?
This trial has 14 study locations across Connecticut, New York, Tennessee, Ontario, Navarre. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How Clinical Trials Work
Understand phases 1-4, trial design, randomization, and the informed consent process.
Patient Rights in Clinical Trials
Your rights as a participant: consent, withdrawal, privacy, and who to contact.
Finding the Right Clinical Trial
A practical guide to searching trials, understanding eligibility, and evaluating options.
All Guides
Browse our complete library of clinical trial educational resources.
Read our methodology — how this data is sourced, computed, and verified.