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COMPLETED

Mechanistic Studies of Phase III Trial With BAF312 in Secondary Progressive Multiple Sclerosis

NCT02330965 · View on ClinicalTrials.gov ↗

Study Summary

The primary goal of this study is to evaluate the effects of BAF312 (siponimod) on select immune and neuronal (nerve) cells by examining laboratory specimens (blood and/or spinal fluid) at multiple time points, prior to, and following the initiation of BAF312 or placebo treatment, in patients with Secondary Progressive Multiple Sclerosis (SPMS) who are enrolled in a clinical trial (NCT01665144) to evaluate the effectiveness and safety of BAF312.

Interventions

  • PROCEDURE Blood Draw
  • PROCEDURE CSF collection by lumbar puncture (Optional)

Study Locations (13)

California

  • Jordan Research & Education Institute: Sutter Alta Bates Summit — Berkeley
  • University of Southern California — Los Angeles
  • University of California, Davis — Sacramento

Michigan

  • University of Michigan Health System -Multiple Sclerosis Center — Ann Arbor
  • Henry Ford Health System — Detroit

Colorado

  • University of Colorado — Aurora

Minnesota

  • Minneapolis Clinic of Neurology — Golden Valley

New Mexico

  • University of New Mexico: Health Sciences Center — Albuquerque

New York

  • South Shore Neurologic Associates - Multiple Sclerosis Care Center — Patchogue

North Carolina

  • Carolinas Medical Center (CMC) — Charlotte

Ohio

  • Cleveland Clinic: Mellen Center for Multiple Sclerosis — Cleveland

Trial Details

FieldValue
Enrollment Target 36 participants
Start Date 2014-12
Est. Completion 2017-07-12

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT02330965

The ClinicalTrials.gov registry entry for NCT02330965 describes a study currently listed as completed. It is categorized as an unspecified phase, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 36 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is National Institute of Allergy and Infectious Diseases (NIAID), which has 1,295 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Secondary Progressive Multiple Sclerosis appearing as the primary indexed condition, and to 2 interventions — of which Blood Draw is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT02330965 reports 13 study locations spanning 10 distinct geographic areas — top geographies include California, Michigan, Colorado. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT02330965 about?

NCT02330965 is a clinical study titled "Mechanistic Studies of Phase III Trial With BAF312 in Secondary Progressive Multiple Sclerosis". The primary goal of this study is to evaluate the effects of BAF312 (siponimod) on select immune and neuronal (nerve) cells by examining laboratory specimens (blood and/or spinal fluid) at multiple time points, prior to, and following the initiation of BAF312 or placebo treatment, in patients with S...

What is the current status of trial NCT02330965?

This trial is currently completed. The enrollment target is 36 participants. The study started on 2014-12. Estimated completion is 2017-07-12.

What conditions does trial NCT02330965 study?

This clinical trial studies the following conditions: Secondary Progressive Multiple Sclerosis. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT02330965?

The interventions under investigation include: Blood Draw (PROCEDURE), CSF collection by lumbar puncture (Optional) (PROCEDURE). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT02330965?

This trial is sponsored by National Institute of Allergy and Infectious Diseases (NIAID), which has 1,295 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT02330965 being conducted?

This trial has 13 study locations across California, Colorado, Michigan, Minnesota, New Mexico. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial