Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT06292923 · ClinicalTrials.gov registry record · Phase 2
A Study of Nasal Foralumab in Non-Active Secondary Progressive Multiple Sclerosis Patients
A Phase 2 study of Secondary Progressive Multiple Sclerosis, sponsored by Tiziana Life Sciences.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 54
- Enrollment target
- 7
- Study locations
NCT06292923: Recruiting Phase 2 study of Secondary Progressive Multiple Sclerosis, sponsored by Tiziana Life Sciences.
NCT06292923 is a Phase 2 study of Secondary Progressive Multiple Sclerosis that is actively recruiting participants, run by Tiziana Life Sciences. The registered enrollment target is 54 participants, below the 490-participant average among 8 other Secondary Progressive Multiple Sclerosis trials with a reported enrollment target (89% lower). The trial reports 7 study locations across 5 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06292923, a Phase 2 study of Secondary Progressive Multiple Sclerosis, is actively recruiting participants, sponsored by Tiziana Life Sciences.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 54 participants
- Enrollment target
- 7
- Study locations
Study Summary
Foralumab is a human anti-CD3 monoclonal antibody being developed for the treatment of autoimmune and inflammatory diseases. The goal of this Phase 2a, randomized, double-blind placebo-controlled, multicenter dose-ranging study is to evaluate the use of nasal foralumab in patients with non-active secondary progressive multiple sclerosis (SPMS). The primary objectives that this study aims to answer are: 1. To determine the safety and tolerability of 50 μg/dose and 100 μg/dose of foralumab nasal compared to placebo 2. To investigate the effect of foralumab relative to placebo on the change from baseline \[18F\]PBR06-positron emission tomography (PET) scans for microglial activation, after 12 weeks (3) months of study treatment.
Conditions Studied
Interventions
- OTHER Placebo
- DRUG Foralumab
Study Locations (7)
Massachusetts
- Brigham and Women's Hospital - Boston
- University of Massachusetts - Worcester
New York
- University of Buffalo - Buffalo
- Cornell Weill Medical Center - New York
Connecticut
- Yale - North Haven
Maryland
- Johns Hopkins - Baltimore
Pennsylvania
- Thomas Jefferson University Hospital - Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 54 participants |
| Start Date | 2023-11-15 |
| Est. Completion | 2025-11 |
| Phase | Phase 2 |
What NCT06292923 shows while recruiting
NCT06292923 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 54 participants, a relatively small participant target, below the 490-participant average among 8 other Secondary Progressive Multiple Sclerosis trials with a reported enrollment target (89% lower).
The record links to 1 condition, with Secondary Progressive Multiple Sclerosis appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT06292923 lists 7 locations in 5 states (Massachusetts, New York, Connecticut).
Frequently Asked Questions
What is clinical trial NCT06292923 about?
NCT06292923 is a clinical study titled "A Study of Nasal Foralumab in Non-Active Secondary Progressive Multiple Sclerosis Patients". Foralumab is a human anti-CD3 monoclonal antibody being developed for the treatment of autoimmune and inflammatory diseases. The goal of this Phase 2a, randomized, double-blind placebo-controlled, multicenter dose-ranging study is to evaluate the use of nasal foralumab in patients with non-active s...
What is the current status of trial NCT06292923?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 54 participants. The study started on 2023-11-15. Estimated completion is 2025-11.
What conditions does trial NCT06292923 study?
This clinical trial studies the following conditions: Secondary Progressive Multiple Sclerosis.
What interventions are being tested in trial NCT06292923?
The interventions under investigation include: Placebo (OTHER), Foralumab (DRUG).
Who is sponsoring clinical trial NCT06292923?
This trial is sponsored by Tiziana Life Sciences, which has 6 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06292923 being conducted?
This trial has 7 study locations across Connecticut, Maryland, Massachusetts, New York, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Secondary Progressive Multiple Sclerosis
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06292923's enrollment target sits among peer trials
54 6th of 8 higher than 3 of 8 other Secondary Progressive Multiple Sclerosis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Secondary Progressive Multiple Sclerosis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
A Study of Orelabrutinib in Patients With Secondary Progressive Multiple Sclerosis
RECRUITING · Phase 3
-
Functional Outcomes From Diets in Multiple Sclerosis
RECRUITING · NA
-
Best Available Therapy Versus Autologous Hematopoietic Stem Cell Transplant for Multiple Sclerosis (BEAT-MS)
RECRUITING · Phase 3
-
A Study to Investigate Long-term Safety and Tolerability of Tolebrutinib in Participants With Multiple Sclerosis.
ACTIVE NOT RECRUITING · Phase 3
-
A Study to Assess the Effectiveness and Safety of Mayzent in Chinese Patients With Relapsing Forms of Multiple Sclerosis
COMPLETED
-
Mechanistic Studies of Phase III Trial With BAF312 in Secondary Progressive Multiple Sclerosis
COMPLETED
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01269853 · 54 participants · Phase 1
Repeated Super-selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Relapsed GBM and AA
- NCT02390752 · 54 participants · Phase 1
Phase I Trial of TURALIO(R) (Pexidartinib, PLX3397) in Children and Young Adults With Refractory Leukemias and Refractory Solid Tumors Including Neurofibromatosis Type 1 (NF1) Associated Plexiform Neurofibromas (PN) and Tenosynovial Giant Cell Tumor ...
- NCT02991248 · 54 participants · NA
Improve Dynamic Lateral Balance of Humans With SCI
- NCT02993900 · 54 participants · NA
Image-Guided Gynecologic Brachytherapy
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI