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NCT02323698 · ClinicalTrials.gov registry record · Phase 1
Effects of Caffeine and Intermittent Hypoxia on Leg Function in Human Spinal Cord Injury
A Phase 1 study, sponsored by Spaulding Rehabilitation Hospital.
- Completed
- Registry status
- Phase 1
- Development phase
- 36
- Enrollment target
NCT02323698: Completed Phase 1 study, sponsored by Spaulding Rehabilitation Hospital.
NCT02323698 is a Phase 1 study that has completed, run by Spaulding Rehabilitation Hospital. The registered enrollment target is 36 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (40% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02323698, a Phase 1 study, has completed, sponsored by Spaulding Rehabilitation Hospital.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 36 participants
- Enrollment target
Study Summary
Accumulating evidence suggests that repeatedly breathing low oxygen levels for brief periods (termed intermittent hypoxia) is a safe and effective treatment strategy to promote meaningful functional recovery in persons with chronic spinal cord injury (SCI). The goal of the study is to understand how caffeine may augment the effects of intermittent hypoxia on motor function and spinal plasticity (ability of the nervous system to strengthen neural pathways based on new experiences) following SCI.
Primary Outcome
Speed will be assessed using the time required to walk 10 meters (10MWT) relative to baseline.
Interventions
- OTHER Placebo
- DRUG Caffeine
- OTHER AIH
- OTHER SHAM
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 36 participants |
| Start Date | 2019-01-01 |
| Est. Completion | 2022-02-19 |
| Phase | Phase 1 |
What the finished NCT02323698 record still lists
NCT02323698 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 36 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (40% lower).
The record links to 0 conditions, and to 4 interventions - of which Placebo is the first listed.
NCT02323698 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02323698 about?
NCT02323698 is a clinical study titled "Effects of Caffeine and Intermittent Hypoxia on Leg Function in Human Spinal Cord Injury". Accumulating evidence suggests that repeatedly breathing low oxygen levels for brief periods (termed intermittent hypoxia) is a safe and effective treatment strategy to promote meaningful functional recovery in persons with chronic spinal cord injury (SCI). The goal of the study is to understand how...
What is the current status of trial NCT02323698?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 36 participants. The study started on 2019-01-01. Estimated completion is 2022-02-19.
What interventions are being tested in trial NCT02323698?
The interventions under investigation include: Placebo (OTHER), Caffeine (DRUG), AIH (OTHER), SHAM (OTHER).
Who is sponsoring clinical trial NCT02323698?
This trial is sponsored by Spaulding Rehabilitation Hospital, which has 101 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02323698's enrollment target sits among peer trials
36 1210th of 2000 higher than 743 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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