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NCT02301065 · ClinicalTrials.gov registry record
Analysis of T Cell and Natural Killer (NK) Cell in Relation to Viral Infections in Pediatric Stem Cell Transplant Patients and Donors
A clinical trial, sponsored by St. Jude Children's Research Hospital.
- Completed
- Registry status
- 35
- Enrollment target
NCT02301065: Completed study, sponsored by St. Jude Children's Research Hospital.
NCT02301065 is a clinical trial that has completed, run by St. Jude Children's Research Hospital. The registered enrollment target is 35 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02301065 has completed, sponsored by St. Jude Children's Research Hospital.
- COMPLETED
- Registry status
- 35 participants
- Enrollment target
Study Summary
Viral infections and reactivation during pediatric allogeneic hematopoietic stem cell transplantation (HSCT) are a common occurrence and significantly contribute to post-transplant morbidity and mortality. The risk is high due to prolonged periods of immune deficiency while awaiting immune reconstitution post-transplant. Current strategies to reduce complications from viral infections include prophylactic treatment, close monitoring for viral infections and prompt treatment at the first sign of symptoms or increasing viral load. However, the most definitive treatment for viral infections remains the host's cellular defenses. Improved understanding of the immune systems response to viral infections may lead to better treatment strategies. This study is being done to explore the relationships between T-cells and NK cells (infection fighting cells) and viral infections or reactivations in young allogeneic stem cell transplant patients. The investigators will be looking at how these cells react and function in young patients receiving allogeneic stem cell transplantation, as well as in healthy stem cell donors.
Primary Outcome
Blood samples will be drawn as follows: * Donors will have a blood sample drawn once within 1 week prior to stem cell donation. * HSCT recipients will have serial blood samples: a baseline sample within 1 week prior to stem cell infusion and collections every 2 weeks, up to 100 days post-transplantation Summary statistics of the two cell populations, such as mean, median, range, and standard error, will be provided.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 35 participants |
| Start Date | 2016-10-13 |
| Est. Completion | 2017-02-06 |
What the finished NCT02301065 record still lists
NCT02301065 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 35 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT02301065 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02301065 about?
NCT02301065 is a clinical study titled "Analysis of T Cell and Natural Killer (NK) Cell in Relation to Viral Infections in Pediatric Stem Cell Transplant Patients and Donors". Viral infections and reactivation during pediatric allogeneic hematopoietic stem cell transplantation (HSCT) are a common occurrence and significantly contribute to post-transplant morbidity and mortality. The risk is high due to prolonged periods of immune deficiency while awaiting immune reconstit...
What is the current status of trial NCT02301065?
This trial is currently completed. The enrollment target is 35 participants. The study started on 2016-10-13. Estimated completion is 2017-02-06.
Who is sponsoring clinical trial NCT02301065?
This trial is sponsored by St. Jude Children's Research Hospital, which has 410 total clinical trials registered on ClinicalTrials.gov.
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