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NCT02213484 · ClinicalTrials.gov registry record
Micro RNAs as a Marker of Aortic Aneurysm in Hereditary Aortopathy Syndromes
A clinical trial of Turner Syndrome and Marfan Syndrome, sponsored by University of Colorado, Denver.
- Completed
- Registry status
- 20
- Enrollment target
- 2
- Study locations
NCT02213484: Completed study of Turner Syndrome and Marfan Syndrome, sponsored by University of Colorado, Denver.
NCT02213484 is a study of Turner Syndrome and Marfan Syndrome that has completed, run by University of Colorado, Denver. The registered enrollment target is 20 participants, below the 518-participant average among 14 other Turner Syndrome trials with a reported enrollment target (96% lower). The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02213484, a study of Turner Syndrome and Marfan Syndrome, has completed, sponsored by University of Colorado, Denver.
- COMPLETED
- Registry status
- 20 participants
- Enrollment target
- 2
- Study locations
Study Summary
The primary objective of this study is to determine whether specific patterns of circulating micro-ribonucleic acids (miRNAs) are associated with aortic aneurysm and dissection in patients with hereditary aortopathy syndromes. The most common of these syndromes is Marfan Syndrome (MFS), but several other recognized aortopathy syndromes are well characterized. The investigators propose the use of a simple blood test, from which miRNA profiles can be measured in individuals with aortopathy syndromes to be compared with miRNAs observed in a control population that has no known predisposition for aortic disease. The investigators hypothesize that microRNA profiles in individuals with Marfan syndrome, and related disorders, will be distinct from those seen in a control group. The investigators predict that up- or down-regulation of certain miRNAs will correlate with the presence and severity of aortic aneurysm, responses to medical therapy, and ultimately could be used to determine when an individual may be at risk of dissection.
Primary Outcome
In a cross-sectional analysis, characterize circulating miRNA profiles in individuals with Marfan syndrome and compare to profiles in normal age-matched controls.
Conditions Studied
Study Locations (2)
Colorado
- Children's Hospital Colorado - Aurora
- University of Colorado Hospital - Aurora
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2014-07-01 |
| Est. Completion | 2016-07-01 |
What the finished NCT02213484 record still lists
NCT02213484 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 518-participant average among 14 other Turner Syndrome trials with a reported enrollment target (96% lower).
The record links to 5 conditions, with Turner Syndrome appearing as the primary indexed condition, and to 0 interventions.
NCT02213484 reports a single indexed study location in Colorado.
Frequently Asked Questions
What is clinical trial NCT02213484 about?
NCT02213484 is a clinical study titled "Micro RNAs as a Marker of Aortic Aneurysm in Hereditary Aortopathy Syndromes". The primary objective of this study is to determine whether specific patterns of circulating micro-ribonucleic acids (miRNAs) are associated with aortic aneurysm and dissection in patients with hereditary aortopathy syndromes. The most common of these syndromes is Marfan Syndrome (MFS), but several ...
What is the current status of trial NCT02213484?
This trial is currently completed. The enrollment target is 20 participants. The study started on 2014-07-01. Estimated completion is 2016-07-01.
What conditions does trial NCT02213484 study?
This clinical trial studies the following conditions: Turner Syndrome, Marfan Syndrome, Loeys-Dietz Syndrome, Thoracic Aortic Aneurysm and Dissection Syndromes, Ehlers-Danlos Type IV Syndrome.
Who is sponsoring clinical trial NCT02213484?
This trial is sponsored by University of Colorado, Denver, which has 1,283 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02213484 being conducted?
This trial has 2 study locations across Colorado. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT02213484's enrollment target sits among peer trials
20 14th of 14 the lowest of 14 other Turner Syndrome trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Turner Syndrome trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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