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COMPLETED Phase 2

Combination Chemotherapy Before and After Surgery in Treating Patients With Localized Pancreatic Cancer

NCT02047474 · View on ClinicalTrials.gov ↗

Study Summary

This phase II trial studies how well combination chemotherapy before and after surgery works in treating patients with localized pancreatic cancer. Drugs used in chemotherapy, such as leucovorin calcium, fluorouracil, irinotecan hydrochloride, and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving combination chemotherapy before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. Giving these treatments after surgery may kill any tumor cells that remain after surgery.

Interventions

  • DRUG oxaliplatin
  • PROCEDURE therapeutic conventional surgery
  • DRUG fluorouracil
  • DRUG leucovorin calcium
  • DRUG irinotecan hydrochloride

Study Locations (9)

Connecticut

  • Smilow Cancer Hospital at Fairfield — Fairfield
  • Smilow Cancer Hospital at Guilford — Guilford
  • Smilow Cancer Hospital at St. Francis Hospital — Hartford
  • Yale University — New Haven
  • Smilow Cancer Hospital at North Haven — North Haven
  • Smilow Cancer Hospital at Orange — Orange
  • Smilow Cancer Hospital at Torrington — Torrington
  • Smilow Cancer Hospital at Trumbull — Trumbull
  • Smilow Cancer Hospital at Waterbury — Waterbury

Trial Details

FieldValue
Enrollment Target 46 participants
Start Date 2014-03-25
Est. Completion 2024-01-14
Phase Phase 2

Sponsor

Yale University

1,283 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT02047474

The ClinicalTrials.gov registry entry for NCT02047474 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 46 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Yale University, which has 1,283 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 5 conditions, with Acinar Cell Adenocarcinoma of the Pancreas appearing as the primary indexed condition, and to 5 interventions — of which oxaliplatin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT02047474 reports 9 study locations spanning 1 distinct geographic area — top geographies include Connecticut. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT02047474 about?

NCT02047474 is a clinical study titled "Combination Chemotherapy Before and After Surgery in Treating Patients With Localized Pancreatic Cancer". This phase II trial studies how well combination chemotherapy before and after surgery works in treating patients with localized pancreatic cancer. Drugs used in chemotherapy, such as leucovorin calcium, fluorouracil, irinotecan hydrochloride, and oxaliplatin, work in different ways to stop the grow...

What is the current status of trial NCT02047474?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 46 participants. The study started on 2014-03-25. Estimated completion is 2024-01-14.

What conditions does trial NCT02047474 study?

This clinical trial studies the following conditions: Acinar Cell Adenocarcinoma of the Pancreas, Duct Cell Adenocarcinoma of the Pancreas, Stage IIA Pancreatic Cancer, Stage IIB Pancreatic Cancer, Stage I Pancreatic Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT02047474?

The interventions under investigation include: oxaliplatin (DRUG), therapeutic conventional surgery (PROCEDURE), fluorouracil (DRUG), leucovorin calcium (DRUG), irinotecan hydrochloride (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT02047474?

This trial is sponsored by Yale University, which has 1,283 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT02047474 being conducted?

This trial has 9 study locations across Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial