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NCT01983826 · ClinicalTrials.gov registry record · NA
Dietary Nitrates and Vascular Function in Patients With Peripheral Artery Disease
A NA study, sponsored by University of Iowa.
- Completed
- Registry status
- NA
- Development phase
- 21
- Enrollment target
NCT01983826: Completed NA study, sponsored by University of Iowa.
NCT01983826 is a NA study that has completed, run by University of Iowa. The registered enrollment target is 21 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01983826, a NA study, has completed, sponsored by University of Iowa.
- COMPLETED
- Registry status
- NA
- Development phase
- 21 participants
- Enrollment target
Study Summary
The overarching question addressed in the current project is: Does dietary nitrate supplementation (8 weeks) improve physiological function in patients with peripheral arterial disease (PAD)? The investigators will specifically address whether dietary nitrate supplementation enhances blood vessel function, blood pressure regulation, and exercise capacity. The proposed project uses an array of clearly defined measurements which will allow investigators to quantify blood vessel function (vasodilator responsiveness and arterial stiffness), blood pressure (variability and responsiveness to stress), and functional capacity before and after 8 weeks of dietary supplementation.
Primary Outcome
Forearm and calf blood flow will be measured independently by venous occlusion plethysmography using mercury-in-silastic strain gauges. Plethysmographic measurements will be made at rest and following 5 minutes of ischemia (reactive hyperemia) of the distal limb (forearm and calf). Peak blood flow will be determined as the highest flow recorded during the post deflation period. Total blood flow will be measured as the area under the time-curve after resting flow is subtracted. Vascular conductan
Interventions
- OTHER Placebo
- DIETARY_SUPPLEMENT Sodium Nitrate
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 21 participants |
| Start Date | 2013-11 |
| Est. Completion | 2016-06-30 |
| Phase | NA |
What the finished NCT01983826 record still lists
NCT01983826 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 21 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT01983826 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01983826 about?
NCT01983826 is a clinical study titled "Dietary Nitrates and Vascular Function in Patients With Peripheral Artery Disease". The overarching question addressed in the current project is: Does dietary nitrate supplementation (8 weeks) improve physiological function in patients with peripheral arterial disease (PAD)? The investigators will specifically address whether dietary nitrate supplementation enhances blood vessel fu...
What is the current status of trial NCT01983826?
This trial is currently completed. It is a NA study. The enrollment target is 21 participants. The study started on 2013-11. Estimated completion is 2016-06-30.
What interventions are being tested in trial NCT01983826?
The interventions under investigation include: Placebo (OTHER), Sodium Nitrate (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT01983826?
This trial is sponsored by University of Iowa, which has 228 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01983826's enrollment target sits among peer trials
21 1762nd of 2000 higher than 233 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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