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NCT01852448 · ClinicalTrials.gov registry record
Genetics of Insulin and Incretins in Cystic Fibrosis
A clinical trial of Cystic Fibrosis, sponsored by Children's Hospital of Philadelphia.
- Recruiting
- Registry status
- 550
- Enrollment target
- 2
- Study locations
NCT01852448 is a study of Cystic Fibrosis that is actively recruiting participants, run by Children's Hospital of Philadelphia. The registered enrollment target is 550 participants, above the 176-participant average among 169 other Cystic Fibrosis trials with a reported enrollment target (213% higher). The trial reports 2 study locations across 1 state.
The verdict
NCT01852448, a study of Cystic Fibrosis, is actively recruiting participants, sponsored by Children's Hospital of Philadelphia.
- RECRUITING
- Registry status
- 550 participants
- Enrollment target
- 2
- Study locations
Study Summary
Cystic fibrosis related diabetes (CFRD) is associated with worse CF-relevant outcomes. The mechanisms underlying CFRD development are not fully understood, but recent evidence suggests Type 2 Diabetes Mellitus (T2DM) mechanisms may be involved and may involve incretins (gut secreted hormones that augment insulin secretion in response to a nutrient load). This study will examine the prevalence of Genome wide association study (GWAS)-implicated T2DM alleles (including TCF7L2) across the spectrum of glucose abnormalities in CF and will use this information to compare incretin and insulin secretion in non-diabetic children and adults with high risk and low risk alleles.
Conditions Studied
Interventions
- GENETIC Blood or Saliva Sample Collection
Study Locations (2)
Pennsylvania
- The Children's Hopsital of Philadelphia - Philadelphia
- The University of Pennsylvania - Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 550 participants |
| Start Date | 2013-05 |
| Est. Completion | 2026-07 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01852448
The ClinicalTrials.gov registry entry for NCT01852448 describes a study currently listed as recruiting, categorized as an unspecified phase. The registered enrollment target is 550 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 176-participant average among 169 other Cystic Fibrosis trials with a reported enrollment target (213% higher). The listed sponsor is Children's Hospital of Philadelphia, which has 431 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Cystic Fibrosis appearing as the primary indexed condition, and to 1 intervention - of which Blood or Saliva Sample Collection is the first listed.
NCT01852448 reports 2 study locations spanning 1 distinct geographic area - top geographies include Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT01852448 about?
NCT01852448 is a clinical study titled "Genetics of Insulin and Incretins in Cystic Fibrosis". Cystic fibrosis related diabetes (CFRD) is associated with worse CF-relevant outcomes. The mechanisms underlying CFRD development are not fully understood, but recent evidence suggests Type 2 Diabetes Mellitus (T2DM) mechanisms may be involved and may involve incretins (gut secreted hormones that a...
What is the current status of trial NCT01852448?
This trial is currently recruiting. The enrollment target is 550 participants. The study started on 2013-05. Estimated completion is 2026-07.
What conditions does trial NCT01852448 study?
This clinical trial studies the following conditions: Cystic Fibrosis.
What interventions are being tested in trial NCT01852448?
The interventions under investigation include: Blood or Saliva Sample Collection (GENETIC).
Who is sponsoring clinical trial NCT01852448?
This trial is sponsored by Children's Hospital of Philadelphia, which has 431 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01852448 being conducted?
This trial has 2 study locations across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
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