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NCT01852448 · ClinicalTrials.gov registry record
Genetics of Insulin and Incretins in Cystic Fibrosis
A clinical trial of Cystic Fibrosis, sponsored by Children's Hospital of Philadelphia.
- Recruiting
- Registry status
- 550
- Enrollment target
- 2
- Study locations
NCT01852448: Recruiting study of Cystic Fibrosis, sponsored by Children's Hospital of Philadelphia.
NCT01852448 is a study of Cystic Fibrosis that is actively recruiting participants, run by Children's Hospital of Philadelphia. The registered enrollment target is 550 participants, above the 176-participant average among 169 other Cystic Fibrosis trials with a reported enrollment target (213% higher). The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01852448, a study of Cystic Fibrosis, is actively recruiting participants, sponsored by Children's Hospital of Philadelphia.
- RECRUITING
- Registry status
- 550 participants
- Enrollment target
- 2
- Study locations
Study Summary
Cystic fibrosis related diabetes (CFRD) is associated with worse CF-relevant outcomes. The mechanisms underlying CFRD development are not fully understood, but recent evidence suggests Type 2 Diabetes Mellitus (T2DM) mechanisms may be involved and may involve incretins (gut secreted hormones that augment insulin secretion in response to a nutrient load). This study will examine the prevalence of Genome wide association study (GWAS)-implicated T2DM alleles (including TCF7L2) across the spectrum of glucose abnormalities in CF and will use this information to compare incretin and insulin secretion in non-diabetic children and adults with high risk and low risk alleles.
Primary Outcome
To examine the prevalence of GWAS-implicated T2DM alleles (including TCF7L2) across the spectrum of glucose abnormalities in children and adults with CF.
Conditions Studied
Interventions
- GENETIC Blood or Saliva Sample Collection
Study Locations (2)
Pennsylvania
- The Children's Hopsital of Philadelphia - Philadelphia
- The University of Pennsylvania - Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 550 participants |
| Start Date | 2013-05 |
| Est. Completion | 2026-07 |
What NCT01852448 shows while recruiting
NCT01852448 is an observational study that tracks outcomes without assigning an intervention. The registered 550 participants enrollment target is mid-sized for trials with a published cap, above the 176-participant average among 169 other Cystic Fibrosis trials with a reported enrollment target (213% higher).
The record links to 1 condition, with Cystic Fibrosis appearing as the primary indexed condition, and to 1 intervention - of which Blood or Saliva Sample Collection is the first listed.
NCT01852448 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT01852448 about?
NCT01852448 is a clinical study titled "Genetics of Insulin and Incretins in Cystic Fibrosis". Cystic fibrosis related diabetes (CFRD) is associated with worse CF-relevant outcomes. The mechanisms underlying CFRD development are not fully understood, but recent evidence suggests Type 2 Diabetes Mellitus (T2DM) mechanisms may be involved and may involve incretins (gut secreted hormones that a...
What is the current status of trial NCT01852448?
This trial is currently recruiting. The enrollment target is 550 participants. The study started on 2013-05. Estimated completion is 2026-07.
What conditions does trial NCT01852448 study?
This clinical trial studies the following conditions: Cystic Fibrosis.
What interventions are being tested in trial NCT01852448?
The interventions under investigation include: Blood or Saliva Sample Collection (GENETIC).
Who is sponsoring clinical trial NCT01852448?
This trial is sponsored by Children's Hospital of Philadelphia, which has 431 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01852448 being conducted?
This trial has 2 study locations across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Cystic Fibrosis
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT01852448's enrollment target sits among peer trials
550 10th of 169 higher than 160 of 169 other Cystic Fibrosis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Cystic Fibrosis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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