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NCT03465774 · ClinicalTrials.gov registry record
Indwelling Pleural Catheters With or Without Doxycycline in Treating Patients With Malignant Pleural Effusions
A clinical trial of Pleural Neoplasm, sponsored by M.D. Anderson Cancer Center.
- Recruiting
- Registry status
- 208
- Enrollment target
- 1
- Study location
NCT03465774: Recruiting study of Pleural Neoplasm, sponsored by M.D. Anderson Cancer Center.
NCT03465774 is a study of Pleural Neoplasm that is actively recruiting participants, run by M.D. Anderson Cancer Center. The registered enrollment target is 208 participants. The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03465774, a study of Pleural Neoplasm, is actively recruiting participants, sponsored by M.D. Anderson Cancer Center.
- RECRUITING
- Registry status
- 208 participants
- Enrollment target
- 1
- Study location
Study Summary
This study is designed to obtain preliminary data comparing indwelling pleural catheters (IPCs) versus IPCs plus doxycycline for pleurodesis as treatments for malignant pleural effusion (MPE). Indwelling pleural catheters (IPCs) are commonly used to treat pleural effusions (build-up of fluid in the lungs). Doxycycline is an antibiotic that is also used to treat pleural effusions. The goal of this clinical research study is to learn if adding doxycycline to the use of an IPC can lead to shorter treatment times with IPCs.
Primary Outcome
This outcome will be analyzed by cause-specific hazard Cox model with treatment group as a covariate. Whenever a catheter is removed, the cause for removal will be documented. For the analysis, causes will include removal due to decreased drainage (i.e., as per plan) as well as removal due to complications (e.g. infection, empyema, refractory pain) or other reasons (e.g. catheter plugged but no complication to the patient, patient preference without a complication). We will also analyze time to
Conditions Studied
Interventions
- OTHER Survey Administration
- OTHER Questionnaire Administration
- DRUG Doxycycline
- DEVICE Indwelling Catheter
- PROCEDURE Quality-of-Life Assessment
Study Locations (1)
Texas
- M D Anderson Cancer Center - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 208 participants |
| Start Date | 2018-03-08 |
| Est. Completion | 2028-12-01 |
What NCT03465774 shows while recruiting
NCT03465774 is an observational study that tracks outcomes without assigning an intervention. The registered 208 participants enrollment target is mid-sized for trials with a published cap.
The record links to 1 condition, with Pleural Neoplasm appearing as the primary indexed condition, and to 5 interventions - of which Survey Administration is the first listed.
NCT03465774 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT03465774 about?
NCT03465774 is a clinical study titled "Indwelling Pleural Catheters With or Without Doxycycline in Treating Patients With Malignant Pleural Effusions". This study is designed to obtain preliminary data comparing indwelling pleural catheters (IPCs) versus IPCs plus doxycycline for pleurodesis as treatments for malignant pleural effusion (MPE). Indwelling pleural catheters (IPCs) are commonly used to treat pleural effusions (build-up of fluid in the ...
What is the current status of trial NCT03465774?
This trial is currently recruiting. The enrollment target is 208 participants. The study started on 2018-03-08. Estimated completion is 2028-12-01.
What conditions does trial NCT03465774 study?
This clinical trial studies the following conditions: Pleural Neoplasm.
What interventions are being tested in trial NCT03465774?
The interventions under investigation include: Survey Administration (OTHER), Questionnaire Administration (OTHER), Doxycycline (DRUG), Indwelling Catheter (DEVICE), Quality-of-Life Assessment (PROCEDURE).
Who is sponsoring clinical trial NCT03465774?
This trial is sponsored by M.D. Anderson Cancer Center, which has 2,692 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03465774 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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