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ACTIVE NOT RECRUITING Phase 2

Carfilzomib, Lenalidomide, and Dexamethasone Before and After Stem Cell Transplant in Treating Patients With Newly Diagnosed Multiple Myeloma

NCT01816971 · View on ClinicalTrials.gov ↗

Study Summary

This phase II trial studies how well carfilzomib, lenalidomide, and dexamethasone before and after stem cell transplant works in treating patients with newly diagnosed multiple myeloma. Carfilzomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Biological therapies, such as lenalidomide, may stimulate the immune system in different ways and stop cancer cells from growing. Drugs used in chemotherapy, such as dexamethasone, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from diving. Giving carfilzomib, lenalidomide, and dexamethasone before and after stem cell transplant may kill more cancer cells

Interventions

  • OTHER laboratory biomarker analysis
  • DRUG dexamethasone
  • DRUG lenalidomide
  • DRUG carfilzomib
  • PROCEDURE autologous hematopoietic stem cell transplantation

Study Locations (5)

Illinois

  • University of Chicago Comprehensive Cancer Center — Chicago

Massachusetts

  • Dana Farber — Boston

Missouri

  • Washington University in St Louis — St Louis

Tennessee

  • Sarah Cannon Cancer Center — Nashville

Ontario

  • Princess Margaret — Toronto

Trial Details

FieldValue
Enrollment Target 76 participants
Start Date 2013-01
Est. Completion 2026-12-01
Phase Phase 2

Sponsor

University of Chicago

846 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT01816971

The ClinicalTrials.gov registry entry for NCT01816971 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 76 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Chicago, which has 846 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 3 conditions, with Stage III Multiple Myeloma appearing as the primary indexed condition, and to 5 interventions — of which laboratory biomarker analysis is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT01816971 reports 5 study locations spanning 5 distinct geographic areas — top geographies include Illinois, Massachusetts, Missouri. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT01816971 about?

NCT01816971 is a clinical study titled "Carfilzomib, Lenalidomide, and Dexamethasone Before and After Stem Cell Transplant in Treating Patients With Newly Diagnosed Multiple Myeloma". This phase II trial studies how well carfilzomib, lenalidomide, and dexamethasone before and after stem cell transplant works in treating patients with newly diagnosed multiple myeloma. Carfilzomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Biological...

What is the current status of trial NCT01816971?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 76 participants. The study started on 2013-01. Estimated completion is 2026-12-01.

What conditions does trial NCT01816971 study?

This clinical trial studies the following conditions: Stage III Multiple Myeloma, Stage II Multiple Myeloma, Stage I Multiple Myeloma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT01816971?

The interventions under investigation include: laboratory biomarker analysis (OTHER), dexamethasone (DRUG), lenalidomide (DRUG), carfilzomib (DRUG), autologous hematopoietic stem cell transplantation (PROCEDURE). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT01816971?

This trial is sponsored by University of Chicago, which has 846 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT01816971 being conducted?

This trial has 5 study locations across Illinois, Massachusetts, Missouri, Tennessee, Ontario. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial